Onco - Lung Bk Path

Question 1

WHO definition of lung cancer

Answer 1

tumors arising from respiratory epithelium (bronchi, bronchioles, alveoli)

Question 2

4 major cell types of lung cancers based on WHO definition

Answer 2

small cell lung cancer
adenocarcinoma
squamous cell carcinoma
large cell carcinoma

Question 3

small cell carcinomas consist of

Answer 3

small cells with scant cytoplasm
ill-defined cell borders
finely granular nuclear chromatin
absent or inconspicuous nucleoli
high mitotic count

Question 4

Neuroendocrine markers that distinguish SCLC from NSCLC

Answer 4

CD56
NCAM
synaptophysin
chromogranin

Question 5

glandular differentiation or mucin production a. Small cell carcinoma

b. adenocarcinoma
c. squamous cell carcinoma
d. large cell carcinoma

Answer 5

B

Question 6

5 types of adenocarcinoma patterns

Answer 6

acinar
papillary
lepidic
solid features
mixture

Question 7

True about squamous cell carcinoma EXCEPT

a. morphologically identical to extrapulmonary squamous cell carcinomas and cannot be distinguished by immunohistochemistry alone
b. Squamous cell tumors show keratinization and/or intercellular bridges that arise from bronchial epith
c. the tumor tends to consists of cells arranged in a concentric manner
d. NOTA

Answer 7

C; sheets of cells

Question 8

This type of lung cancer comprise <10%. they lac cytologic and architectural features of the other three.

Answer 8

Large cell carcinomas

Question 9

Lung CA that can develop in current and former smokers

a. Small cell carcinoma
b. adenocarcinoma
c. squamous cell carcinoma
d. large cell carcinoma

Answer 9

AOTA

Question 10

Lung CA most commonly associated with heavy tobacco smoking

Answer 10

squamous and small cell carcinomas

Question 11

Most frequent histologic subtype of lung CA

Answer 11

adenocarcinoma

Question 12

histologic type of lung cancer most likely in never smokers or former light smokers, <10 pack year hx, women, <60 y.o.

Answer 12

adenocarcinoma

Question 13

Why is it important to differentiate between types of NSCLC

Answer 13

tx

Question 14

T/F most lung cancer present in advanced stage

Answer 14

T

Question 15

T/F the diagnosis of NSCLC not other wise specified is still acceptable

Answer 15

F; must specify for tx

Question 16

TTF-1

a. SCLC
b. squamous
c. adenocarcinoma
d. large cell

Answer 16

C

Question 17

p40

a. SCLC
b. squamous
c. adenocarcinoma
d. large cell

Answer 17

B

Question 18

p63

a. SCLC
b. squamous
c. adenocarcinoma
d. large cell

Answer 18

B

Question 19

napsin A

a. SCLC
b. squamous
c. adenocarcinoma
d. large cell

Answer 19

C

Question 20

term used to describe single-layered growth of atypical cuboidal cells coating the alveolar walls

Answer 20

lepidic growth

Question 21

small solitary adenocarcinomas <=3 cm with either pure lepidic growth or with predominant lepidic growth with <=5mm invasion

Answer 21

adenocarcinoma in situ

minimally invasive adenocarcinoma

Question 22

lepidic-predominant invasive adenocarcinomas

a. favorable prognosis
b. intermediate prognosis
c. poor prognosis

Answer 22

A

Question 23

acinar

a. favorable prognosis
b. intermediate prognosis
c. poor prognosis

Answer 23

B

Question 24

solid predominant

a. favorable prognosis
b. intermediate prognosis
c. poor prognosis

Answer 24

C

Question 25

terms eliminated from the variants of invasive lung carinoma

Answer 25

signet ring

clear cell adenocarcinoma

Question 26

term a subtype with a particularly poor prognosis has been added (adenocarcinoma)

Answer 26

micropapillary

Question 27

3 subtypes of squamous cell carcinoma subtypes

Answer 27

keratinizing
nonkeratinizing
basaloid