New Neurobiology Flashcards
Which of the RF pathways go into the Cerebellum ?
serotonergic
noradrenergic
How can you tell the difference between the serotonergic and noardrenergic pathways ?
serotonergic goes into corpus callosum
What is the nuclei and the role of the serotonergic pathways ?
Raphe nucleus magnus
sleep/mood and emotional behaviour
What is the nuclei and the role of the cholinerigc pathways?
Nucleus of meynert- basal forebrain
memeory learning
What is the nuclei and the role of the dopaminergic pathways ?
VTA
Act on D1/D2 receptors in the putamen circuit
What is the nuclei of the noradrenergic pathways ?
locus coereleus
attention
learning
memory and mood
What is the role of the anterior corticospinal tract ?
Proximal
decussates at the spinal chord level
What is the role of the lateral corticospinal tract ?
Distal musculature
decussates at the medulla
What is the role of the rubrospinal tract ?
excitation of flexors
What is the role of reticulospinal tract ?
flexors
What is the role of the tectospinal tract ?
orientation to visual stimuli- tracking
What is the role of the lateral vestibuospinal tract ?
antigravity muscles
What is the role of the medial reticulospinal tract ?
regulate head movements.
Where does the abducens lie ?
on the pons
What joins to the ponto-medullary junctions ?
VI
VII
VIII
What joins to the post olivary sulcus ?
IX
X
XI
What joins to the preolivary sulucus ?
XII
What is the nucleus ambiguus ?
IX
X
XI
What is the role of the inferior colliculus ?
Spatial localisation of sound
Sound travels to the MGN via the inferior colliculus in the auditory pathway
What is the role of the superior colliculus ?
involved in the optic pathway
fibres travel in the optic tract to the superior coliculus and the LGN
What is the role of the globus pallidus in relation to the thalamus ?
globus pallidus interior is inhibitory to the thalamus.
What is the striatum ?
composed of the caudate and the putamen
What is huntingtons disease a result of ?
loss of acetylcholinergic input to the striatum.
Where is the trochlear nerve located ?
on the dorsal side of the brainstem
What is the output of the fastigial nucleus ?
floculonodular lobe
What are the nuclei found in the vermis of the cerebellum ?
Fastigial nucleus
What are the nuclei found in the intermediate zone of the vermis ?
interposed nucleus
What are the nuclei found in the cerebellar hemispheres ?
Dentate nucleus
What are the nuclei found in the flocuonodular lobe ?
Fastigial nucleus
What do lesions to the spinocerbellum lead to ?
ataxia
What do lesions in the vestibulocerebellum lead to ?
staggering gait
What do lesions in the neocerbellum lead to ?
slow movement onset
How do the basal ganglia act ?
ipsilaterally
What are the basal ganglia ?
Putamen Globus Pallidus interior and exterior Sub thalamic Substantia nigra Caudate
What is the role of the basal ganglia ?
they tend to inhibit unwanted movements- the prevent unwanted movements
What is the basic feedback system that the basal ganglia are a part of ?
Basal ganglia to the cortex via the ventral anterior and ventral lateral nuclei of the thalamus
What is the striatum ?
caudate and putamen
What is the corpus striatum ?
caudate putamen and globus pallidus
What is the putamen circuit ?
subconscious execution of planned movements
What is the caudate circuit ?
cognitive planning of movement
What is parkinsons disease a result of ?
loss of dopamine from the substantia nigra - loss of nigrostriatal projections
Is parkinsons a hyperkinetic or hypokinetic disorder ?
hypokinetic
What is huntingtons disease a result of ?
loss of cholinergic input to the striatum
Is huntingtons a hyperkinetic or jypokinetic disorder ?
hyperkinetic
Describe the direct pathway ?
Dopmaine acts on D1 receptors in the striatum
this inhibits the globus pallidus interior
this reduces inhibition of the thalamus and increases cortical activity
Describe the indirect pathway ?
dopamine acts on D2 receptors
this inhibits the globus pallidus exterior
this reduces subthalamic inhibition
this excites the globus pallidus interior
this reduces thalamic and cortical excitation.
What are the alar lamina ?
sensory
lateral
What are the basal lamina ?
motor
medial
What are general somatic afferents ?
general sensation from skin, skeletal muscle , joint and bone
What are special somatic afferent ?
vision hearing and balance
What are general visceral afferent ?
visceral organs
What are special visceral afferent ?
taste and visceral sense
What are special visceral efferent
skeletal muscle from the pharyngeal arches
What are general somatic efferent ?
skeletal muscle from somites
What are general visceral efferent ?
Parasympathetic- muscles and glands
Where do cranial nerve I and II attach ?
diencephalon
Where do cranial nerve III-XII attach ?
brainstem
What are the entirely sensory cranial nerves ?
optic
olfactory
vestibulocohlear
What are the entirely motor cranial nerves ?
oculomotor trochlear abducens spinal accessory Hypoglossal
What are the sensory and motor cranial nerves ?
facial
trigeminal
vagus
Glossopharyngeal
What are the parasympathetic cranial nerves ?
oculomotor
glossopharyngeal
vagus
facial
What is the nucleus ambiguus ?
IX
X
XI muscles of the pharynx,larynx and soft palate
What is the edinger westphal nucleus ?
oculomotor
to the iris and ciliary muscles
What is the superior salivatory nucleus ?
lacrimal
submandibular
sublingual
VII
What is the inferior salivatory nucleus ?
parotid
IX
What is the nucleus of the solitary tract ?
VII IX and X
Anterior and posterior tongue and the epiglottis
What are the 3 primary brain vesicles ?
Prosencehalon
Mesencephalon
Rhomencephalon
What does the prosencephalon divide into ?
Diencephalon- thalamus
Tentencephalon- Cerebral hemispheres
What does the mesencephalon divide into ?
midbrain
What does the rhomebncepahlon divide into ?
metencephalon- pons and cerebellum
Myelencepahlon- medulla
What is the wall of the lateral ventricle ?
cerebral hemisphere
What is the wall of the third ventricle ?
thalamus
What is the wall of the IVth ventricle ?
pons and medulla
What is the wall of the cerebral aqueduct ?
midbrain
What does the opthalmic artery supply ?
retina
cranial dura
What is locked in syndrome ?
basillar artery- has pontine branhes- supply pons which is route for all ascending and descending pathways
What is the difference between dendrites and axons ?
dendrites- taper and have spines
axons- dont taper and dont have spines
What is the motor protein used in fast anterograde transport ?
kineisin
What protein coats neurotransmiter vesicles ready for exocytosis ?
clathrin
What is temporal summation ?
adding together of firing of many EPSPs from the same presynaptic neurone at high frequency to trigger an AP in the postsynaptic neurone
What is spatial summation ?
adding together of many EPSPs from many presynaptic neurones to trigger an AP
What are the modaliites carried by the DCML ?
fine touch
pressure
vibration
proprioception