Nephrotic syndrome Flashcards
how does the glomerular filtration barrier work
blood enters the glomerulus via afferent arteriole user high pressure
filtarte is formed in bowman capsule by fluid passing across the walls of the capillary and nephron
what is the capillary hydrostatic pressure in the glomerulus
45 mmHg
what is the hydrostatic pressure in bowman space
10 mmHg
what is the plasma protein oncotic pressure
25 mmHg
describe the layers of the glomerular barrier from the bowman capsule to the capillary lumen
bowman capsule epithelial foot process slit membrane lamina rara lamina densa lamina rara endothelial cell fenestra capillary lumen
what are two characteristics of nephrotic syndrome
loss if protein in the urine
injury to the epithelial foot processes of the nephron
what are three ways to lose protein via the urine
proteinuria
hypoalbuminaemia
oedema
how can damage to the epithelial foot processes of the nephron occur
minimal change disease in children
membranous nephropathy
focal segmental glomerulosclerosis
amyloid damage
what does podocyte fusion and collapse mean at the filtration barrier
albumin can pass through into the nephron
what symptom is common in nephrotic syndrome
swollen ankles
what is the treatment for nephrotic syndrome
immunosuppression via steroids such as: cyclophosphamide
tacrolimus
