Large intestine Flashcards

1
Q

describe the anatomical locations from the start to the end of the large intestine

A
terminal ileum 
ileocecal valve 
caecum 
ascending colon 
transverse colon 
descending colon 
sigmoid colon 
rectum
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2
Q

what are haustra

A

small pouches caused by sacculation (sac formation), which give the colon its segmented appearance
Haustral contractions are slow segmenting, uncoordinated movements that occur approximately every 25 minutes.

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3
Q

what is a barium enema

A

X-ray used to detect abnormalities of the large intestine via rectum injection

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4
Q

describe the layers of cells from the ,men to the outside in the large intestine

A
simple columnar epithelium 
mucous cells 
intestinal cells 
intestinal gland 
muscular mucosal
submucosa 
musculares externa
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5
Q

what is the musclaris external made out of in the large intestine

A

longitudinal muscle and circular layer

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6
Q

describe the role of the ileoceacal valve

A

flutter valve is one way
there is periodic relaxation which allows flow to occur
ill distention opens it
caecal distension closes it

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7
Q

what is haustration

A

slow contractions of circular muscle squeeze contents to and fro as in segmentation

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8
Q

what is mass movement

A

few times a day there is a peristaltic wave

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9
Q

what is motility in the colon NOT for

A

moving contents along

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10
Q

what happens to haustra during mass movement

A

they disappear

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11
Q

what is control of the control one by

A

intrinsic via the enteric nervous system (some para control)

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12
Q

where do enteroendocrine and neurocrine influences come from in the colon

A

cells releasing 5-HT and Peptide YY

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13
Q

what reflexes trigger mass movements

A

gastrocolic and orthocolic

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14
Q

what causes digesting in the colon

A

bacteria not enzymes

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15
Q
what do bacteria turn these substances into 
fibre 
urea + amino acids
cysteine/methionine
bilirubin 
primary bile acids 
conjugated bile acids 
fermentation
A
short chain fatty acids such as butyric acid hydrogens nd methane 
ammonia 
hydrogen sulphide
urobilligen and stercobillins
secondary bile acids 
unconjugated bile acids 
1L nitrogen, hydrogen and CO1
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16
Q

how are short chain fatty acids absorbed in the colon

and specific mechanism

A

secondary active transport via Na+ linked transporter
important souche of energy for coloncytes
lumen has SMCT1 symporter with SCFA and Na
Na out the other side and K back in

17
Q

how is salt absorbed in the colon and what is the mechanism

A

ENaC channels apical surface allows transcellular sodium transport - then Na out and K in with K leaking out
paracellular Cl- flux followed by water
stimulated by aldosterone

18
Q

how is chloride secreted in the colon

A

NKCC1 on basal surface brings K 2Cl and Na into cell and Cl out via CFTR which requires cAMP and Ca

19
Q

what causes increase of chloride secretion in colon

A

cholera and E coli toxins increase cAMP

C difficile toxin increases Ca2+

20
Q

what does increases in chloride in the colon cause

A

secretory diarrhoea

21
Q

what happens to k in the colon

A

can undergo absorption and secretion
passive secretion exceeds active
balance determined by plasma K, aldosterone and cAMP

22
Q

what type of muscle is
the internal anal sphincter
external anal sphincter

A

smooth

skeletal

23
Q

describe the process of what happens when faeces enters the rectum

A

feaces enters the rectum and the pressure rises
triggers relaxation of the internal anal sphincter and the urge to defecate
the external anal sphincter contracts

24
Q

what aids in increasing the rectosigmoid angle

A

sitting or squatting

relaxation of the puborectalis muscle

25
Q

what helps to provide motive force for defaecation

A

rectal peristalsis - triggers colonic mass movement plus raised intraabdominal pressure

26
Q

what is valsalva manoeuvre

A

deep breath and contraction of abdominal muscles to aid increases in intraabdominal pressure