Embryology of the Kidney Flashcards

1
Q

what 4 parts are the urinary system made up of

A

kidneys
ureters
urinary bladder
urethra

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2
Q

what two parts are the reproductive system made up of

A

internal/external genitalia

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3
Q

when does the formation of the pronephros occur

A

4th week

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4
Q

describe the formation of the pronephros

A

intermediate mesoderm in the cervical region condenses and reorganises
forms epithelial buds - disappear around day 25

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5
Q

how does the mesonephric duct form

A

intermediate mesoderm in the lower cervical region induced to epithelise forming a solid duct

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6
Q

what does the mesonephric duct fuse with and on what day

A

cloaca on day 26 (develops caudally)

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7
Q

what is the formation of the mesonephros derived from

A

intermediate mesoderm in upper thoracic to upper lumbar regions

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8
Q

what does the development of the mesonephric duct induce

A

formation of the mesonephric buds from mesenchyme

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9
Q

formation of the mesonephric tubules occur in what fashion

A

carniocaudally

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10
Q

what do mesonephric tubules differentiate into

A

S shape and bowman capsule

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11
Q

what is the renal corpuscle made from

A

bowman capsule and glomerulus

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12
Q

what is the glomerulus made out of

A

tuft of capillaries which form at the medial end of the tubule

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13
Q

how many of the cranial-most tubules fun with the mesonephric duct

A

6/7

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14
Q

when do the tubules first start producing small amounts of urine

A

between weeks 6-10

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15
Q

what happens to the mesonephric ducts after week ten

A

males - develop into reproductive structures

females - regress

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16
Q

where does gonadal development take place

A

on the medial aspect of the mesonephric ridge

17
Q

what parts make up the collection portion

A

collecting ducts
major and minor calyces
renal pelvis
ureter

18
Q

what parts make up the excretory portion

A

bowmans capsule
PCT
LoH
DCT

19
Q

what happens to the ureteric buds by day 32

A

penetrate the metanephric mesenchyme

20
Q

what is the biurification pathway after the ureteric bud penetrates the metanephric mesenchyme

A
renal ampulla
renal pelvis 
major calyces 
minor calyces 
collecting ducts
21
Q

what covers newly formed collecting tubules

A

metanephric tissue cap

22
Q

what does the metanephric tissue cap cause

A

specific branching of the tubule

differentiation of cells in the metanephric cap to form renal vesicle

23
Q

what does the renal vesicle turn into

A

s shape tubule and bowman capsule

24
Q

what 3 parts make up the nephron

A

renal corpuscle, tubule and collecting tubule

25
Q

describe duplication of the ureter

A

premature biurification of the ureteric bud
can be partial or complete
present in approx 5%

26
Q

describe unilateral and bilateral renal genesis

A

early degeneration of ureteric bud or failed interaction between ureteric and meseneohric tissue cap
unilateral - generally asymptomatic, hypertrophy of remaining kidney
bilateral - incompatible with life

27
Q

what is oligohydraminos

A

bilateral renal agenesis

decreased volume amniotic fluid causing the foetus to present with potter sequence

28
Q

describe polycystic kidney disease

A

autosomal dominant occurs 1 in 1000
cysts form on all parts of the nephron
autosomal recessive 1 in 5000
cysts form in collecting ducts and kidneys enlarge to renal failure in childhood

caused by gene mutations in cilia

29
Q

what is ascent of kidneys caused by

A

growth and elongation of developing foetus

30
Q

by what week do kidneys fully relocate

A

week 9

31
Q

what is horseshoe kidney

A

occurs in around 1/600 people
inferior poles of kidney fuse
resides lower in the lumbar region
usually asymptomatic

32
Q

what happens to the cloaca in week 4-7

A

divides into the urogenital sinus and the anal canal which are separated by urorectal septum

33
Q

what is the urogenetial sinus divided into

A

upper part - presumptive urinary bladder
pelvic part - urethra
phallic part - penile urethra (males), vestibule (females)

34
Q

what is the bladder initially continuous with

A

allantois

35
Q

what happens to the allantois

A

obliterates to form the urachus that connects the apex of the bladder with the umbilicus in the adult