Intro to nutrition Flashcards

1
Q

what does a healthy diet supply

A

energy, building blocks for metabolism, essential nutrients

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2
Q

what are people eating too much of and too little of

A

to much saturated fat, salt and added sugar

too little fruit, veg, oily fish and fibre

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3
Q
what do these acronyms mean:
EAR 
LRNI
RNI
safe intake
A

estimated average requirement - half need more than this value and half need less than this value - its is the middle of the values
lower reference nutrient intake - sufficient for few people but not meeting 97.5% of the pop - two SD lower than the EAR
RNI - sufficient for 97.5% of the population 2 SD above average
safe intake - sufficient for almost everyone but not so large it causes undesired affects

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4
Q

what does energy expenditure = and what does it depend on

A

energy intake
depends on basal metabolic rate (age, weight and sex)
and the amount of intensity of physical activity

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5
Q

what is the trend between men and women for EAR in adults

A

both slowly decreases as you get older but men is higher than women

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6
Q

what are our main sources of energy

A

fat stores (80-90%)

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7
Q

what happens to muscle during starvation

A

protein from muscle tissue is metabolised to provide amino acids for other reactions

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8
Q

what is the average daily requirement for protein compared to athletes

A

0.75 g/kg/day ie a 75kg male requires 50g protein per day

athletes recommend 12.-1.7 g/kg/day

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9
Q

how much are proteins synthesised and degraded per day

A

250 g per day

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10
Q

in a healthy adult what does nitrogen intake =

A

nitrogen excretion

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11
Q

what is the difference between a negative nitrogen balance vs a positive one

A

positive means you intake more than you excrete and vice versa
positie occurs during growth, pregnancy etc - when building new tissues
negative occurs during fasting or illness where the body is breaking down proteins for energy

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12
Q

what are the 9 essential amino acids

that can’t be synthesised by humans

A
methionine 
valine
histidine
leucine
phenylalanine
tryptophan 
isoleucine
lysine
threonine
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13
Q

what lipids do we need and why

A

triacylglycerols for energy as 1g fat provides 9kcal (39KJ) compared to carbs and protein that provide 4 kcal
cholesterol and fatty acids are precursors for hormones and prostaglandins

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14
Q

what are the 4 different types of fats and what are some examples

A

saturated - no double bonds - found in meat and dairy products
mono-unsaturated - one double bond found in olive and peanut oil
polyunsaturated - more than one double bond - corn and sunflower oil
trans(hydrogenated) - trans double bonds - cakes biscuits and pastry

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15
Q

what do double bonds do to the structure in fatty acids

A

produce a kink

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16
Q

what are the confounding factors in the saturated fat debate

A

variation in study designs
variation in effects of individual fatty acids on serum lipid profile
heterogeneity of LDL particles

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17
Q

for the 4 types of fats what are the recommended % of dietary intake

A
saturated fats - 11% 
cis-monounsaturated - 12% 
cis-polyunsaturated - 6% 
trans-fats - less than 2% 
total less than 35% around 30% desirable
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18
Q

why should we eat 2 portions of oily fish each week

A

good source of omega 3 polyunsaturated fatty acids to decreases risk of heart disease

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19
Q

what are the 4 types of crabs

A

polysaccharides - mainly starch
disaccharides - mainly sucrose
monosaccharides - mainly glucose and fructose
non-starch polysaccharide - dietary fibre

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20
Q

what is the recommended percentage intake of total carbohydrate

A

50%

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21
Q

what is the percentage of energy intake of free sugars

A

10%

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22
Q

what are the two types of micronutrients

A

vitamins - organic compounds for normal metabolic function which cannot be synthesised
minerals - inorganic elements which have a physiological function

23
Q

which vitamins are water soluble vs fat soluble

A

fat soluble - vit E/K/A/D

water soluble - vit C, B1-3/5/6/7/9/12

24
Q

what are the real names of the water soluble vitamins

A
thiamin - b1
riboflavin b2
niacin b3
pantothenic acid b5 
pyridoxal phosphate B6
biotin b7 
folic acid b9
cobalamin b12
vit c - ascorbic acid
25
Q

what is the role and effect of deficiency of thiamin

A

cofactor in decarboxylation reactions such as link reaction and kerb cycle
beri-beri - müsle weakness, nerve damage and can affect heart

26
Q

what is the role and effect of deficiency of riboflavin

A

constituents of co factors eg flavin adenine dinucleotide - involved in fays crabs and proteins
very rare ariboflavinosis - usually is is efficiently conserved in the body

27
Q

what is the role and deficiency of niacin

A

constituent co factor eg NADH

pellagra - diarrhoea, dementia, dermatitis and death

28
Q

what is the role and deficiency of pantothenic acid

A

constituent co enzyme A, energy metabolism and fat metabolism
unknown - found almost in all foods so do deficiency

29
Q

what is the role and deficiency of biotin

A

prothetic group - acts as a carrier for co2 in carboxylation reactions eg fat synthesis
very rare to have a deficiency

30
Q

what is the role and deficiency of pyridoxal phosphate

A

cofactor for enzymes involved in protein metabolism, haem synthesis, neurotransmitter synthesis and modules steroid hormone action
deficiency leads to irritability, depression, confusion and inflammation of the tongue and mouth

31
Q

what is the role an deficiency of folic acid

A

1-C transfers particularly in DNA synthesis

neural tube defects, spina bifida, anencephaly, macrolytic anaemia

32
Q

what is the role and deficiency of cobalamin

A

required for methionine synthesis and odd-chain fatty acid metabolism - only found in animal products
deficiency causes macrolytic anaemia, irreversible neurological damage - commonly caused by autoimmune disease preventing absorption

33
Q

what is the role and deficiency of vitamin C

A

collagen synthesis also role in antioxidant

deficiency causes scurvy - weakened collagen

34
Q

what is the role and deficiency of vitamin A

A

vision (rod cell function)
transcriptional regulator
deficiency causes blindness

35
Q

what is the role and deficiency of vitamin D

A

role of bone formation and maintenance - also roles in immune regulation, cell differentiation and muscle function
deficiency causes rickets in children and osteomalacia in adults

36
Q

what is the role and deficiency of Vit E

A

acts as an antioxidant, its main role if to prevent lipid oxidation in membrane
deficiency in fatmalabsorbtion (eg CF) causes neurological problems

37
Q

what is the role and deficiency of vit K

A

cofactor for enzymes which activate blood clotting proteins - may also be involve din bone maintenance
rare def in healthy adults but deficiency in new borns causes bleeding

38
Q

what are the key minerals that we need

A

iron zinc iodine calcium magnesium fluoride phosphate sodium and potassium

trace elements of cobalt, copper, chromium, manganese and selenium

39
Q

what is the recommended daily intake of sodium

what is the risk in high sodium

A

less than 6 g / day

increases risk of CVD

40
Q

what are factors of inadequate diet

A

food availability (poverty / disability)
food choices
problems with eating (dysphagia)

41
Q

what are the factors associated with inadequate absorption

A
problems with fat absorption affects fat soluble vitamins (cystic fibrosis, coeliac disease, crowns disease)
pernicious anaemia ( B12 absorption)
42
Q

what is iron deficiency anaemia caused by

A

often arises from persistent blood loss from gastric ulceration, colon cancer or excessive menstrual loss

43
Q

when is folic acid deficiency common in women

A

during pregnancy

44
Q

what is the definition of malnutrition

A

inadequate or excess intake of protein, energy and micronutrients such as vitamins and minerals

45
Q

which deficiencies cause the greatest effect to the body

A

iron, vit a, iodine, zinc

46
Q

what is scurvy

A

vitamin C deficiency - found mainly within Uk low income population (found more commonly in men)

47
Q

what is vit D deficiency and which areas of the Uk are most at risk during which seasons

A

winter and mainly spring - northern regions of the UK

vit D is formed in the presence of UV light in the skin - causes osteomalacia in adults and rickets in kids

48
Q

which community are most at risk to B12 deficiency

A

vegans who don’t take supplements

49
Q

what is pernicious anaemia

A

caused by Vit 12 deficiency which can lead to irreversible neurological damage - common signs are tingling of toes and fingertips - can ultimately lead to death if untreated

50
Q

why is folic acid needed during pregnancy

A

folic acid is vital for DNA synthesis

without enough folic acid it causes neural tube defects such as anaecphaly, spina bifida

51
Q

what does deficiency in iodine do during pregnancy

A

can cause cognitive defects in children

52
Q

what are the guidelines for macronutrients

A
starchy foods - 40% energy intake 
5 portions of fruit / veg 
moderate amounts of protein 
moderate amounts of milk and dairy 
less saturated fats, salt and sugar
53
Q

what are the guidelines for micronutrients

A

pregnant women should take 400 micro grams of folic acid until the 12th week of pregnancy
children under 5 may need vit ADC sups
all individuals are advised to take 10 micro grams per day of vit D