CF Flashcards
1
Q
what is cystic fibrosis
A
genetic condition that’s causes internal organs especially lungs and digestive system to become clogged with spicy mucus resulting in chronic infections and inflammation of the lungs
2
Q
how common is cystic fibrosis, what is the gene in effect and is there a cure
A
1 in 4 recessive genetic inherited condition CFTR gene affect around 11k in UK medan life expectancy 37 years no cure
3
Q
what are the symptoms of CF
A
airways clogged with mucus - hard to breath chest infection and lung damage difficult to digest food struggle to retain weight stomach cramps
4
Q
why do people with CF have a high fat diet
A
pancreatic insufficient mutation dependant
helps fight off infection
more energy
helps retain weight
5
Q
describe the association between diabetes and CF
A
around 50% of adults with CF have diabetes
combo of type 1 and 2
managed with insulin
6
Q
what are other related complications with CF
A
osteoporosis liver disease deny disease arthritis asthma infertility in males bowel cancer
7
Q
what are 3 CFTR modulators which target the underlying condition
A
kalydeco
orkambi
symkevi
