Naloxone

Question 2

What class of drug is Naloxone Hydrochloride?

Answer 2

Opioid antagonist, antidote.

Question 3

What is the mechanism of action of Naloxone?

Answer 3

inhibits narcotic receptor sites. Reverses respiratory depression secondary to opiate drugs.

Question 4

What are the indications for using Naloxone?

Answer 4

Opiate overdose, reversal of CNS and respiratory depression induced by opioids, decreased LOC & coma of unknown origin.

Question 5

What are the contraindications for Naloxone use?

Answer 5

Do not use on a newborn if the mother is addicted to narcotics, may cause withdrawal. Use with caution in narcotic-dependent patients and neonates of narcotic-addicted mothers.

Question 6

What are the adverse reactions or side effects of Naloxone?

Answer 6

cardiac arrest, dyspnea, dysrhythmias, diaphoresis, hypertension, N/V, pulmonary edema, pulmonary edema, restlessness, seizures, tachycardia, withdrawal symptoms

Question 7

What is a notable caution when administering Naloxone?

Answer 7

Seizures without causal relationship have been reported. May not reverse hypotension. Use caution when administering to narcotic addicts (potential violent behavior).

Question 8

What is the half-life consideration for Naloxone?

Answer 8

Half-Life of naloxone is often shorter than the half-life of narcotics; repeat dosing may be required. In cardiac arrest, naloxone is generally not beneficial.

Question 9

What is the dosage and administration for adults using Naloxone?

Answer 9

0.4 to 2 mg IM, IV, IO, SQ, ET, IN. Repeat every 2-3 minutes if needed to 10 mg total dose.

Question 10

What is the duration of action for Naloxone?

Answer 10

Onset: < 2 Minutes, Peak effect: Variable, Duration: 30 - 60 Minutes.