Glucagon

Question 1

Class of Glucogon

Answer 1

Hyperglycemic Agent

Question 2

MOA of Glucagon

Answer 2

Increases blood glucose levels by stimulation of glycogenolysis. Unknown mechanism of stabilizing cardiac rhythm in beta blocker OD’s. Minimal positive inotropic and chronotropic response. Decreases GI motility & secretions.

Question 3

Indications for Glucagon

Answer 3

AMS r/t hypoglycemia. May be used as a reversal agent in beta-blocker & calcium channel blocker OD’s.

Question 4

Contraindications for Glucagon

Answer 4

Hyperglycemia & Hypersensitivity

Question 5

Adverse reactions for Glucagon

Answer 5

Dizziness, N/V, Tachycardia, (3 H’s) HA, HTN, Rebound Hypoglycemia

Question 6

IMPORTANT NOTE for Glucagon

Answer 6

Ineffective if Glucagon stores are depleted. Should always be used in conjunction with D50. Requires reconstitution w/the supplied solution. Incompatible in solution with most other substances.

Question 7

Dosage for Glucagon

Answer 7

Hypoglycemia: 0.5-1mg (unit) IV/IM/SQ

Beta-blocker or Calcium Channel blocker OD: 3-10mg IV, over 3-5 mins, followed by 3-5mg/hr infusion as needed.

Question 8

Onset. Peak. Duration of Glucagon

Answer 8

Onset: 1 Min

Peak: 5-20 Min

Duration: 60-90 Min