Midazolam

Question 1

Class of Midazolam

Answer 1

Benzodiazepine

Question 2

MOA of Midazolam

Answer 2

Reversibly interacts with GABA receptors in the CNS causing sedative, anxiolytic, amnesic, and hypnotic effects.

Question 3

Indications for Midazolam

Answer 3

Seizures, Chemical restraint, sedation for medical procedures (intubation, Cardioversion, vent pts)

Question 4

Contraindications for Midazolam

Answer 4

Alcohol intoxication, Coma, acute narrow-angle Glaucoma, OD, Shock, depressed Vital signs.Concomitant with Alcohol, Barbiturates, CNS Depressants, & Narcotics.

Question 5

Adverse Reactions of Midazolam

Answer 5

Apnea, decreased BP, Cardiac/respiratory arrest, Respiratory depression, HA, decreased HR, Hypotension, N/V, Pain at injections site, Solemnance.

Question 6

Dosages for Midazolam

Answer 6

Adult Seizure: IV: 5-15mg, SLOWLY, titrate to pt response. May repeat in 10-15 min.

IN: 0.2mg/kg, max dose of 10mg.

Ped Seizure: 0.1-0.3mg/kg IV/IM.

Procedural Sedation: 0.5-2.5mg IV, SLOWLY. May be repeated up to total dose of 0.1mg/kg.

Question 7

Onset, Peak, Duration of Midazolam

Answer 7

Onset: 1-3 min

Peak: Variable

Duration: 2-6hrs, dose dependent

Question 8

Important note for Midazolam

Answer 8

Requires continuously monitoring of respiratory & cardiac function. Decrease dose by 50% in older pts & in pts with hepatic & renal dysfunction. IM/IN routes control seizures faster than IV if vascular access has not been obtained.