Morphine

Question 1

Class of Morphine

Answer 1

Schedule 2 drug

Opioid Analgesic

Question 2

MOA of Morphine

Answer 2

Alleviates pain through CNS action. Suppresses fear & anxiety centers in the brain. Depresses brainstem respiratory centers. Increases peripheral venous capacities & decreases venous return. Decreases preload & afterload, which decreases myocardial oxygen demand.

Question 3

Indications for Morphine

Answer 3

Severe heart failure, acute cardiogenic pulmonary edema, chest pain associated with AMI, analgesic for moderate/severe acute/chronic pain.

Question 4

Contraindications for Morphine

Answer 4

Head Injury, COPD exacerbation, depressed respiratory drive, hypotension, abdominal pain, decreased LOC, hypovolemia, labor, pts who have taken MAOI’s with the last 14 days, could cause paradoxical excitation.

Question 5

Adverse Reactions of Morphine

Answer 5

Apnea, Bradycardia, Bronchospasm, Confusion, CNS & Respiratory depression, Dry mouth, Dyspnea, HA, Hypotension, Orthostatic Hypotension, N/V, Sedation, Syncope, Tachycardia

Question 6

Dosages of Morphine for Adults

Answer 6

STEMI: Initial dose 2-4mg SLOW IVP over 2-5 mins

NSTEMI: 1-5mg, IM/IV/IO, may repeat every 5 mins PRN, max total dose of 10mg.

Question 7

Dosages of Morphine for Peds

Answer 7

0.1-0.2mg/kg per dose, IV/IO/IM/SQ, max dose 5mg.

Question 8

Duration of Action for Morphine

Answer 8

Onset: less than 2 mins

Peak: 20 mins

Duration: 2-7hrs