lilley ch 52 antiemetic and antinausea drugs

Question 1

Unpleasant feeling that often precedes vomiting

Answer 1

nausea

Question 2

Forcible emptying of gastric and, occasionally,

intestinal contents

Answer 2

emesis (vomiting)

Question 3

where do signals come from that stimulate chemoreceptor trigger zone (3)

Answer 3

• GI tract
• inner ear
• cerebral cortex

Question 4

7 categories antiemetic drugs

Answer 4

• anticholinergics
• antihistamines
• antidopaminergics
• neurokinin antagonists
• prokinetics
• serotonin blockers
• tetrahydrocannabinoids

Question 5

example anticholinergic antiemetic drug and what its used for

Answer 5

scopalamine

*motion sickness

Question 6

3 examples antihistamine antiemetics

Answer 6

• dramamine
• benadryl
• meclizine

Question 7

3 examples antidopaminergic antiemetics and what they’re used for

Answer 7

• prochlorperazine
• promethazine
• droperidol
• used for psychotic disorders or intractable hiccups

Question 8

3 examples neurokinin antagonist antiemetics and what they’re used for

Answer 8

• aprepitant
• fosaprepitant
• rolapitant
• used for acute and delayed vomiting associated with chemotherapy

Question 9

example prokinetic antiemetic and what its used for

Answer 9

metoclopramide

*GERD

Question 10

4 examples serotonin blocker antiemetics and what they’re used for

Answer 10

• dolasetron
• granisetron
• ondansetron
• palonosetron
• chemotherapy N/V

Question 11

example tetrahydrocannabinoid antiemetic and what its used for

Answer 11

dronabinol

*anorexia associated with pts with AIDS and cancer

Question 12

herbal product used for nausea

Answer 12

ginger

Question 13

3 adverse effects ginger

Answer 13

• anorexia
• N/V
• skin reactions

Question 14

drug interaction with ginger

Answer 14

increase bleeding risk with anticoagulants

Question 15

when are antiemetics given with chemotherapy

Answer 15

30-60 mins before chemo