Lilley Ch 44 (anti-inflammatory drugs) Flashcards
Localized protective response stimulated by injury to tissues, which serves to destroy, dilute, or wall off (sequester) both the injurious agent and the injured tissue
inflammation
4 functions of NSAIDs
- analgesic
- antipyretic
- platelet inhibition
- anti-inflammatory
5 chemical categories of NSAIDs
salicylates acetic acid derivatives COX2 inhibitors enolic acid derivatives propionic acid derivatives
NSAID: Shown to reduce cardiac death after myocardial infarction
aspirin
COX pathway: (prostaglandin beneficial body effects) has a role in maintaining the gastrointestinal (GI) mucosa
COX1 (aspirin inhibits)
COX pathway: prostaglandins involved in inflammation
COX2
conditions that are contraindications for NSAID use
peptic ulcer disease
vitamin K deficiency
important adverse effects of NSAIDs to note
- GI bleeding
- acute renal failure
- blackbox warning for heartattack and stroke
- tinnitus
what is low dose aspirin used for
thromboprevention
type of NSAID: inhibits platelet aggregation, antithrombotic effect, ex: aspirin
salicylates
what disease is associated with the use of aspirin while combatting an infection (ex: chickenpox)
reye syndrome
aspirin + acetaminophen + caffeine
excedrin
aspirin-antacid combinations
bufferin
acetic acid derivative: use for PDA, OR/AR, preterm labor
incodin
acetic acid derivative: short term use for pain
toradol
