lilley ch 44 antigout drugs

Question 1

drug Used to prevent uric acid production and to prevent acute tumor lysis syndrome

Answer 1

allopurinol

Question 2

drug Inhibits the reabsorption of uric acid in the kidneys

and thus increases the excretion of uric acid

Answer 2

probenecid

Question 3

drug Reduces inflammatory response to the deposits of
urate crystals in joint tissue
 Used for short-term management or prevention of
gout

Answer 3

colchicine

Question 4

complications colchicine (2)

Answer 4

• short term leukopenia

- bleeding into GI/urinary tracts

Question 5

uric acid transport inhibitor

given with atleast 2 L of fluids a day

Answer 5

lesinurad

Question 6

adverse effects allopurinol (3)

Answer 6

• exfoliative dermatitis
• stevens johnson syndrome
• toxic epidermal necrolysis

Question 7

Inhibits the reabsorption of uric acid in the

kidney, increasing the excretion of uric acid

Answer 7

probenecid

Question 8

2 herbal products used to treat OA

Answer 8

• glucosamine

- chondroitin

Question 9

adverse effects glucosamine and chrondroitin (3)

Answer 9

• GI discomfort
• skin reactions
• headache, drowsiness

Question 10

2 drug interactions glucosamine and chrondroitin

Answer 10

• enhances effect warfarin

- increased insulin resistance

Question 11

contraindications to NSAIDs (2)

Answer 11

• GI lesions, peptic ulcer disease

- bleeding disorders

Question 12

what should NSAIDs be taken with

Answer 12

food, milk, or antacids