Lecture - Resp (Bevin Physiol 6 Gas Transport)

Question 1

How does reduced PB or FIO2 lead to arterial hypoxaemia?

Question 2

If you are hypoxic, what three things should you check to find out the cause?

Answer 2

So there are five mechanisms:

1. Reduced PB or FIO2
   - the third unknown thing to check
2. Hypoventilation
   - assess using PaCO2

3, 4 and 5. Gas exchange problem (diffusion, shunt or VQ mismatch)

-measure A-a

Question 3

1. Explain how hypoventilation leads to arterial hypoxemia?
2. Explain the causes of it too
3. Is it reversible?

Question 4

Clinically, what are the teo types of respiratory failures you see?

Answer 4

-

Question 5

What do you get in terms of CO2 if you have hypo and hyperventilation?

Answer 5

Hyper and hypocapnia

Question 6

Okay hypercapnia - pH problems

1. We produce like 13000mmol of CO2/day - why is this potentially 13000mmol of acid?
2. So why dont we die of resp acidosis?
3. What is the worst thing you can do?

Answer 6

2. We breathe it out
3. Not breathe

Question 7

So explain in terms of the CO2 equation what happens when you get respiratory acidosis and alkalosis

Question 8

So how do you have compensation for respiraptry acidosis or alkalosis?

Which orga compensates?

Question 9

Where can you get metaboli acidosis and how do the lungs compensate?

Question 10

How is O2 carried in the blood?

What are the two ways and tell me what you know about what they depend on

Question 11

What is:

• O2 saturation?
• O2 capacity?
• O2 content?

Question 12

Explain the O2 saturation curve

-Can you reliably draw it wth numbers?

Question 13

What is 2,3 BPG and how does it work? When does it increase etc?

Question 14

What is cyanosis?

What are the types of cyanosis and which one is more of a problem?

How do you which of the types of cyanosis soeone has?