Lecture - Cancer - In situ and Invasive Neoplasia

Question 1

Precancerous Leisons

1. Certain non-neoplastic conditions and certain benign neoplasms havea well definied increased risk of what?
2. What are precancerous leisons?
3. The epithelial leisons range from what to what?
4. Do all these leisons progress to invasive cancer?
5. Because of their usually ____ _____ and their non-_____ nature, microscopic leisons are unlikely to cause symptoms or to be detected using ____ ______
6. But, precancerous leisons have the greatest

Question 2

UV Damage:

1. How do you get UV damage? Like, what gets damaged and can’t repair?
2. As with other carconogens, UV__ causes mutations in what two things?
3. In particular, mutatant forms of the _____ and _____ genes have been deleted both in human skin cancers and in UVB-induced cancers in mice

Question 3

Skin Cancer

1. UV rays induce an increased incidence of what 3 things?
   - what does SCC look like grossly and histologically?
2. What are the rates like in NZ?

Question 4

Pre-cancerous solar ketatoses

1. The degree of risk depends on what four things?
2. What ynderlies these leisons? Like, what is this? (look at sticky notes)
3. Can you easily differentiate between this and a carcinoma?

Question 5

Solar Ketatoses

1. Before the development of overt malignancy of the epidermins, what occurs?
2. What is this confined by?
3. Do all solar/actinic ketatoses lead to skin cancer?
4. What is the treatment?
5. What does it look like grossly? And histologically?

Question 6

Carcinoma of the Uterine Cervix

1. First, what is the brief anatomy of the cervix? Like where is:
   - uterus
   - cervix
   - vagina
   - what does the cervix look like after childbirth?
   - transformation zone - what’s on either side of this?
2. Cervical squamous cell carcinoma contains what in 95% of cases?
   - Which type is most common?
3. Specific HPV types are associated with”
   - cervical cancer - ____ risk - _____ leisons
   - condylomata - ____ risk - _____ leisons (what do they look like?)
4. Describe a condyloma histologically - what cells do they also have in the middle?
5. With flat leisons, what is the clinical scenria in terms of the timeline

Question 7

Oncogenic DNA viruses

1. The genomes of oncoggenic DNA viruses do what that can remain in a latent state for years?
2. How is the virus integrated into the host DNA in cancers?
   - How does it present?
3. Viral proteins have a role in neoplastic transformation by what?
4. HPV ____ and ____ proteins block what and remove what?
   - how do these two do this?
   - what even is p53?
   - idk if you should bother with the E7 stuff
5. Look at slide 25 for further simplification
6. What does telomerase have to do with this?
7. SO yeah, HPV is an oncogenic DNA virus - so what happens after the exposure to it? Like, if you met someone who just got HPV, how will you explain to them the prognosis? (flow chart on slide 28)

Question 8

Cervical dysplasia - in situ

1.

Question 9

On this picture, which one is the

• normal
• cancer
• high grade CIN?
• low grade CIN?

Question 10

1. What are the two types of cervical sampling and how do they work?
2. What should you see histologically with these two methods?

Question 11

What does severe dysplasia look like with a biopsy?

Question 12

1. What does CIN stand for?
2. What is the equivlanet for CIN1,2,3 etc
3. In which test do you use these two different set of terms?

Slide 38

Question 13

WHat does a carcinoma look like in the uterine cervix?

-histologically and grossly

Question 14

What are the survival rates with cervical carcinoma at its different stages