Lecture 1 MSK - Skin

Question 1

You know the functions of skin, right? Explain each of these with an example:

1. Protective
2. Sensory
3. Excretory
4. Metabolic
5. Thermoregulatory

Answer 1

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Question 2

What’s the difference between thick and thin skin? What layer determines the thickness?
Where would you find the thick skin and where would you find the thin skin?

Answer 2

1. I think hair and epidermis thickness is the difference between thick and thin skin.

Question 3

What of the four basic tissue types is the epidermis and the dermis/hypodermis?

Answer 3

Epi and CT respectively

Question 4

1. What cell type in the epidermis?
2. What is the arrangement of cells in the epidermis?
3. What is the function of this arrangement?
4. 5. Cells differentiate from the b____ l____ (stem cells)
5. Cells are joined by d_____
6. What is the purpose of the d_____?
7. What is the corneum?
8. Why is keratin synthesised?

Answer 4

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Question 5

1. How is the epidermis formed?

2. Five layers - what are they and what happens in each?

Answer 5

1. It has keratinocytes in layers.

Question 6

Explain the stages of the life cycle of a keratinocyte

Answer 6

The basal cell (cuboidal) moves up through the different stages and different genes are turned on and off during this.

It then becomes a spinous cell and starts to synthesise keratin. Interdigitation of the cell membrane helps with fitting more desmosomes and resist the shearing forces.

Then it becomes a granular cell - full of keratohyaline granules. Also makes lipids and stores these for the water barrier. Golgi making lipids and the lipids are released on surface of cell. The lipids make an impermeable barrier.

Question 7

Difference between keratohyaline and keratin?

Answer 7

Keratohyalin is associated with eleidin, the intermediate between keratohyalin and keratin

Question 8

Go read slide 19

Answer 8

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Question 9

1. Name the three things that make up the basement membrane

2. What are these: HD, D, L, F, C on the basal cell

Answer 9

• By the way, fibroreticular and anchoring fibrils aren’t the same

Question 10

Where new the melanocytes located and what do they produce and what is the function of that? Why are some people whiter than others?

Is there desmosomal attachment among melanocytes?

Answer 10

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Question 11

What are two other types of cells located in the epidermis and what’s their function?

Answer 11

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Question 12

What are the four epidermal derivates and what do they do?

Answer 12

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Question 13

What are the two types of layers in the dermis?

Answer 13

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Question 14

The dermis contains 5 things - why:

1. Fibroblasts
2. Plasma cells/macrophage
3. Pathway for v____ and n____ tissue and g____ ducts
4. C____ for flexibility and tensile strnght
5. E____ for elasticity

Answer 14

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Question 15

What does the hypodermic contain?

Answer 15

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Question 16

Where do find meissner’s corpuscles and what are they?

What are used to detect pain and temperature?

Answer 16

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Question 17

What dates pressure and where is it? It’s surrounded by capsule of S____ cells

Answer 17

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Question 18

Whereabouts are the eccrine sweat glands? What are they there for?

Answer 18

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