Lecture - Pathology (Asthma)

Question 1

Asthma

1. Is it reversible or irreversible?
2. What sort of symptoms do you get with asthma?
3. What’re the triggers for asthma attacks mainly?
4. Jusr saying but it’s a complex chronic inflammation of bronchial mucosa
5. So this is reversibble airways obstruction but what is chronic obstructive aireays disease? SO like, how are asthma and COPD diffeernt?

Question 2

What’s the three different classifications of asthma? Like, what can induce it?

Question 3

Alright, for asthma:

1. What is the core abnormality?
2. What are the two types of inflammtion?
3. What does each of the inflammtion lead to: high or low asthma
4. What’re the treatment options for each of the types of iinflammtion?

Question 4

Aetiology for asthma

1. What two things interact to give ‘Early intermittent asthma’ and what are the examples?
2. What will those two things and ‘Early intermittent asthma’ sometimes lead to?
   - is this type of asthma reversible?

Question 5

What is the hygiene hypothesis and how does it relate to a see saw?

Question 6

Is asthma a heriditary thing? Like if the parents have it, is the kid mroe likely to get it too?

So some geners obviously influence the asthma susceptibility and severity but other genes modify ______ to _______ (pharmacogenomics)

Question 7

What is ADAM 33?

Question 8

From Annika’s lecture, what are the two things that we learnt about how epigetics influence gene expression?

-Just know that RNA interference is a third

Question 9

Airway obstruction in asthma

What are the three things that cause the obstruction?

Question 10

On slide 21, explain the pathophysiology

Question 11

Airway immune responses

1. What hypersensitivity is the Early Phase response?
2. What AB and cell is invovled?
3. What hypersensitivity is the Late Phase response?
4. What’s the cells involved?

Question 12

Okay, what’re the cellular responses to allergens

Aka summarise slide 23

Question 13

Explain how mast cells degranulate - slide 24

Question 14

Inflammation in asthma phases

-you’ve talked about the early and late phase, but what’s the third phase?

Question 15

In the pathphysiology, you said bronchospams was a thing - what is it?

Also, what’s the deal with this mucosal changes?

Question 16

What does the sputum of someone who’s coughed up stuff in asthma look like?

Question 17

Airway remodelling

1. What happens to the basememnt membrane?
2. What about mucus stuff?
3. Name the three other things that haopen

Question 18

What happens in an asthma attack

• regarding the general description
• airflow
• PEFR and FEV1
• how is it usually resolved?

Question 19

What’re the causes of asthma attack?

Question 20

1. What is occupational asthma?
2. What is occupational exposure?
3. What’re the characterisiics of sensitizer-induced occupational asthma and irritant-induced asthma?