Lecture 43: Male Reproductive Microanatomy Flashcards
2 compartments of testis parenchyma
seminiferous tubules
interstitial tissue
seminiferous tubules: function
where spermatogenesis takes place
interstitial tissue of testis: function
steroidogenesis
what cells secrete androgens and where do they do this
leydig cells
interstitial tissue of testis
testis: stroma
connective tissue
fills space in between seminiferous tubules
support
2 cell types in seminiferous epithelium: seminiferous tubules
sertoli cells
germ cells
4 types of germ cells in seminiferous epithelium
elongated spermatids
rounded spermatids
spermatocytes
spermatogonia
4 types of germ cells in seminiferous epithelium: rank based on least differentiated to most differentiated
least: spermatagonia –> spermatocytes –> rounded spermatids –> elongated spermatids
location of spermatogonia in seminiferous epithelium
most basal
spermiation
release of sperm into lumen
what induces differentiation of spermatogonia
growth factors
sertoli cells: 4 functions
-provide physical and nutritional support to germ cells
-mediate movement of cells and molecules across epithelium
-phagocytize degenerating germ cells
-secrete molecules into epithelium and interstitial tissue
where is the blood-testis barrier located
seminiferous epithelium
blood testis barrier is formed from
cell membrane of sertoli cells and tight junctions between adjacent sertoli cells
blood testis barrier: 4 functions
create 2 compartments in seminiferous epithelium
protect germ cells from autoimmune response
sequester and secrete proteins, ions and carbs that are required by germ cells
2 compartments created by blood testis barrier
adluminal
basal
2 germ cells contained within adluminal compartment: seminiferous epithelium
spermatocytes
spermatids
2 germ cells contained within basal compartment: seminiferous epithelium
spermatogonial stem cells
differentiating spermatogonia
tubular wall of seminiferous tubules: made of
laminin
fibronectin
collagen
what 2 cells contribute to forming the basal lamina: seminiferous tubules
sertoli
peritubular myoid
what is found within interstitial tissue of testis (5)
leydig cells
blood vessels, lymphatic vessels, nerves, macrophages
leydig cells
synthesize and secrete androgens
2 steps of spermatogenesis
1) spermatocytogenesis
2) spermiogenesis
spermatocytogenesis: process
first step of spermatogenesis
undifferentiated stem cell –> spermatogonium –> mitosis –> primary spermatocyte –> meiosis I –> secondary spermatocyte –> meiosis 2
spermiogenesis
after meiosis II
meiosis 2 –> early spermatid –> sperm
excurrent ducts of testis: function
carry sperm through fluid to epididymis
2 components of excurrent ducts
-rete testis
-efferent ducts