Kidney numbers pt 2 Flashcards by Rae Perry

Plasma oncotic pressure in afferent arteriole:

28 mmHg

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Plasma oncotic pressure in beginning of glomerular capillaries:

28 mmHg

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Plasma oncotic pressure at the end of glomerular capillaries:

36 mmHg

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Hydrostatic pressure of the tubule:

18 mmHg

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Protein osmotic pressure in the early part of the tubule:

0 mmHg

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Net filtration pressure of kidney:

10 mmHg

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Filtration rate of kidney:

125 mL/min

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KF (filtration coefficient) in kidney:

12.5 mL/min/mmHg

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How to solve for filtration coefficient?

Filtration rate / NFP

In kidney:
125 mL/min (filtration rate) divided by 10 mmHg (NFP) = 12.5 mL / min / mmHg

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How did we get NFP of the kidney?

Take the pressure that promotes filtration - pressures that oppose filtration

60 mmHg (BP in glomerular capillaries) - 32 mmHg (osmotic pressure of glomerular capillaries) - 18 mmHg (Hydrostatic pressure of the tubule) = 10 mmHg

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Filtration rate equation

Filtration rate = NFP x KF

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Relaxation of the efferent arteriole = ____ upstream pressure, ___ filtration

reduced, less

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Constriction of the efferent arteriole = ___ upstream pressure, ___ filtration

higher, more

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BP at the end of the efferent arteriole

18 mmHg

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Difference in bp between the glomerular capillaries and end of efferent arteriole

42 mmHg decrease

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What % of stuff that is filtered is reabsorbed?

99%

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What % of stuff that is filtered is excreted?

1-2%

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Renal artery blood pressure

100 mmHg

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Blood pressure of glomerular capillaries

60 mmHg (2x systemic caps)

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Normal GFR

125 mL/min

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Afferent arteriole plasma oncotic pressure

28 mmHg

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Oncotic pressure in the beginning of the glomerular capillaries

28 mmHg

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Oncotic pressure in the end of the glomerular capillaries

36 mmHg

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Oncotic pressure in the middle of the glomerular capillaries

32 mmHg

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Hydrostatic pressure in tubule or bowman's capsule

18 mmHg

Oncotic pressure of tubule or bowman's capsule

0 mmHg

NFP of glomerular capillaries

10 mmHg

Filtration coefficient of glomerular capillaries

12.5 ml/min/mmHg

BP at end of efferent arteriole

18 mmHg

Change in pressure from glomerular capillaries to end of efferent arteriole

42 mmHg 60-18 = 42

Change in pressure from renal artery to glomerular capillaries

40 mmHg 100-60=40

Peritubular capillaries plasma oncotic pressure

32 mmHg

Blood pressure of peritubular capillaries

13 mmHg

Renal interstitial oncotic pressure

15 mmHg

Renal interstitial physical fluid pressure or hydrostatic pressure

6 mmHg

Peritubular capillaries NFP

-10 mmHg

Peritubular capillaries net reabsorption pressure

+10 mmHg

Filtration rate equation

Filtration rate = NFP x Filtration coefficient

A little over ___% of the blood that moves through the kidney is filtered

10%

___ of the plasma that moves through the kidneys gets filtered

1/5

Filtration fraction of kidneys %?

20% GFR (125) divided by renal plasma flow (660 mL/min)

Renal plasma flow in ml/min

660 ml/min

Renal blood flow in ml/min

1100 ml/min

Normal HCT

0.40

How do we get our plasma flow or volume for the kidneys?

Take 0.60 x 1100 (RBF) = 660

Kidneys will autoregulate between these blood pressures:

50-150 mmHg

Normal urine output

1 ml/min

How many nephrons are in each kidney at birth?

1 million

How many nephrons do we have at birth?

2 million (1 mil each kidney)

This percentage of nephrons are cortical nephrons

90-95%

This percentage of nephrons are deep medullary nephrons

5-10%

This percentage of peritubular capillaries are in the outer medulla

90-95%

This percentage of peritubular capillaries are in the inner medulla

5-10%

Where does the pudendal nerve come from

S2, S3, S4

What fraction of almost everything is reabsorbed at the proximal tubule?

2/3

The kidney can remove about ___% of PAH as blood passes through the kidney

90%

The brush border of the proximal tubule increases the surface area of its cells by ____

20 fold

Membrane potential of kidney cells

-70 mV

Proximal tubule tubular lumen charge

-3 mV

The amount of protein filtered each day in a normal healthy person

1.8 grams

How many grams of the filtered normal protein will be reabsorbed by the proximal tubule?

1.7 grams

How much protein shows up in the urine in a normal healthy adult per day?

100 mg or 0.1 grams

Pinocytosis only exists in this part of the kidney

proximal tubule

We reabsorb ___% of the water filtered in the proximal tubule and ___% in the thin descending limb

65%, 20% (so 85% reabsorbed by the time we are at the end of the loop of henle)

Tubular lumen membrane potential in thick loop of henle .WHy does it matter?

+8 mV Pushes divalent cations through the paracellular route

Lizards can get their interstitial up to ___

3000 mOsm

What is the most concentrated our interstitium can be?

1200 mOsm

Plasma oncotic pressure in middle of glomerular capillaries:

32 mmHg