How The Body Responds To Injury Flashcards
What is inflammation
Response to an irritant or infection it is part of an innate immune response
Types of inflammation
Acute, chronic, systemic
What is systemic inflammation
Cytokine induced inflammatory response it occurs over the whole body
Signs of inflammation
Redness, heat, swelling, pain, reduced function
Causes of inflammation
Infection, exposure to chemicals, injury
Causes of chronic inflammation
Resistant infection, autoimmune diseases
Steps of inflammation
Vessel dilation
Vascular permeability
Leukocyte movement which is activated through ligand receptor binding
What is vessel dilation
Increase bloodflow, can have exudation.
Histamine is produced by mast cells which relax smooth muscles and contracts endothelial cells which bind to G coupled receptors
What do you neutrophils do
Reduce inflammation and accumulate near endothelium, transmigration
Phagocytosis relies on
Reactive oxygen species and lysomal enzymes
Phagocytosis is used to eliminate
Necrotic cells and destroys proteins
What are the signalling molecules for the immune system
Cytokinins and chemokines
Compliment factors are produced in
The liver and circulate in the plasma
Compliment factors function
In histamine release and chemotaxis (recruit leukocytes)
What happens in the termination of the inflammatory response
Mediator molecules have short half lives so decay quickly, neutrophils, anti-inflammatory molecules
