Drug Action Mechanisms Flashcards
Mechanisms of action
Direct physiochemical effect
Transport systems
Enzymes
Major types of receptors
Direct physiochemical effect eg laxatives
Don’t bind to receptors
Types of transport systems
Ion channels, cell membrane, ion pumps, transporter proteins
Most drugs inhibit enzymes by
Binding to active site or allosteric active site
What are the 4 main types of receptors
Ionotropic, g-protein coupled, kinase and nuclear
Gs
Increase in adenyl Cyclase causes increased in cAMP and then PKA (protein kinase)
Gq
Increase in PLPC causes increase in DAG and IP3 which causes an increase in Ca2+ and PKC
Gi
Decrease adenyl cyclase causes decrease in cAMP
What is a receptor
A protein molecule on the surface or inside of the cell
What are partial agonists
Slow physiological reaction which has less than 100% response
What are antagonists
They block the physiological response and can be competitive reversible or non competitive and irreversible
What are agonists
Bind to orthosteric binding site and stimulate physiological effects
What is functional antagonism
Drugs that have a posing actions at different receptors cancel each other out
Competitive reversible reactions
Binding to the same allosteric site, the antagonist doesn’t stay there and you can give an extra dose of the medicine to beat the competition
Non-competitive a reversible reactions
Allosteric affect where they bind to different places and change the shape of receptor
