How The Body Recovers From Injury Flashcards
Stages of recovery
Resolution of inflammation
Tissue regeneration
Tissue repair
Scar formation
What is resolution of inflammation
Restoration of tissue back to normal
Small injuries tissue regeneration can
Get full functionality back as tissues can regenerate if they have stem cells
What is first intention in tissue repair
Two sides of injury a line close together in a minor injury
Tissue repair involves the creation of
Scar tissue from collagen and fibres
What do macrophages do
Get rid of damaged tissue, they have some receptors to recognise pathogens or necrosis and apoptotic cells
They circulate in blood as monocytes and tissues have resident macrophages which attack infections early on
Macrophages do
Chemotaxis, phagocytosis and pinocytosis (ingest fluid)
What is chemotaxis
Where macrophages migrate to damaged areas
Stages of phagocytosis (ingesting of cell debris)
Recognition, binding, signalling, phagocytosis
Stages of bone repair
Haematoma formed at fracture site, new bone formed – it’s remodelled depending on mechanical pressure of motion
Can the liver repair itself
Yes as hepatocytes are stable cells so have good regenerative capacity
Permanent cells like the heart neurons and smooth-muscle can’t
Regenerate but all repair to a different method
What is angiogenesis repair
New vessels are formed through proliferation, it involves extracellular matrix proteins for vascular remodelling
Scar formation doesn’t involve
Regeneration but involves connective tissue and skin would healing by second intention
Scar remodelling happens by
Changes in collagen, some blood vessels disappear and some form
