Commensalism & Pathogenesis Flashcards

1
Q

How are infections classified

A

By the causative agent or symptoms

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2
Q

The chain of infection

A

Susceptible host, causative agent, reservoir, portal Of exit, mode of transmission, portal of entry and back to susceptible host

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3
Q

The causative agent can be a microorganism that is

A

Endogenous infection which is inside or exogenous infection (outside)

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4
Q

Examples of reservoir in the chain of infection

A

Environment, animals, humans, soil

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5
Q

Portal of exit examples

A

Cough/sneeze, sweat, saliva, mucus, vomit, faeces, blood, skin contact, sexual contact, spores, urine, tears, bodily fluids

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6
Q

Portal of exit through the

A

Nose, mouth, mammory glands, vagina, urethra, ears, eyes, broken skin, skin, anus, seminal vesicles

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7
Q

Mode of transmission examples

A

Foamities, airborne droplets, direct skin to skin contact/blood, indirect – vectors, contact transmission, droplet, ingestion, inoculation, transplacental

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8
Q

What is foamities

A

Getting a disease from an object by touch

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9
Q

What is transplacental transmission

A

From placenta to fetus

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10
Q

Portal of entry examples

A

Respiratory tract and GI tract

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11
Q

What makes you are more susceptible host

A

Immuno compromised, age, nutrition, social economic factors, open wounds, invasive procedures, already infected

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12
Q

Why are hospital patients more susceptible to infections

A

Because they are already ill, Have more exposure, more infections micro organisms, immunosuppressives drugs, surgery and invasive procedures

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13
Q

How do you break the chain of infection

A

Identify micro organism, disinfect and sterilise, check employer health e.g. their vaccines, clean hospital, masks, aseptic technique, gloves for handling waste, single patient room, PPE, maintain skin and personal hygiene and diet and fluids

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14
Q

What do you use for droplet precautions

A

Masks

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15
Q

What do use for airborne precautions

A

General masks don’t work so they use NP5 masks

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16
Q

What is an acute infection

A

Where the virus infects the host

17
Q

What is a chronic infection

A

Continue infection beyon when immune system should clear it

18
Q

What is a Latent infection

A

The infection enters the DNA genome – DNA viruses go to the retro virus infection which triggers cellular transformation and the genome and keeps dividing

19
Q

What is an asymptomatic infection

A

Infection with no symptoms

20
Q

When is the incubation period

A

In the latent and asymptomatic parts of infection

21
Q

Due to virulence professional pathogens

A

Always cause disease

22
Q

Due to virulence opportunist pathogens

A

Sometimes cause disease

23
Q

What is pathogenicity

A

Probability that an organism is causing disease, it depends on virulent, where it is and immune state of patient

24
Q

What does the coagulative test do

A

Stimulates clotting in staphylococcus aureus

25
Q

S.aureus infection how does it occur

A

Staphylococcus aureus lives in the nose and can cause infection in the skin or through food poisoning

26
Q

The innate immune system is very sensitive to

A

Lipopolysaccharide recognition

27
Q

Lipopolysaccharide recognition

A

LPS interacts with the TLR4 toll like receptors which causes an inflammatory response, coagulation and clotting pathways

28
Q

Gram-negative bacteria in the blood cause

A

Systemic activation of immune response

29
Q

What does clostridium difficile do

A

In the elderly mainly it causes diarrhoea, it makes toxins, produces spores and some very large strains