(F) Cestodes: T. solium and saginata of Cyclophyllidea (module-based) Flashcards
module-based beh
- It has a cosmopolitan distribution
- larval worm infection, called cysticercosis is possible with this species
- some group of people that do not eat pork because of their tradition are unlikely to become infected
TAENIA SOLIUM
TAENIA SOLIUM AKA
Pork tapeworm
TAENIA SOLIUM
larval worm infection is called?
cysticercosis
TAENIA SOLIUM
Where does the adult inhabit?
- upper part of the jejunum with its scolex attached to the mucosa
- body folded back and forth in the lumen of the intestine
TAENIA SOLIUM
life span
may be more than 25 years.
TAENIA SOLIUM
Definitive host and intermediate host
Man is the usual definitive host. Pigs are the intermediate host.
TAENIA SOLIUM
source of the infective stage
oink oink
TAENIA SOLIUM
Size of adult worm
2-7 meters long
TAENIA SOLIUM
Match Morphology:
1. broader than long
2. nearly square
3. longer than broad
4. alternate irregularly at the lateral margins of the segments
5. elliptical groups of follicles, median in position behind the ovary
A. genital pores
B. vitellaria
C. Immature segments
D. mature proglottids
E. gravid segment
CDEAB
TAENIA SOLIUM: MORPHOLOGY
usual number of distinct proglottids
less than 1000
TAENIA SOLIUM: LIFE CYCLE
MOT of Man
ingestion of inadequately cooked pork with cysticercus cellulosae larvae
p’wede rin embryonated egg
need complete
TAENIA SOLIUM: LIFE CYCLE
Stomach juices digest the pork causing the release of the larvae, will evaginate their scolices when they reach the?
upper level of the small intestine
TAENIA SOLIUM: LIFE CYCLE
The worm attaches, by means of the scolex, to the wall of the small intestine and becomes adult after how many weeks?
5-12 weeks
TAENIA SOLIUM: LIFE CYCLE
Eggs escape from the ruptured uterus of the gravid proglottids and are, together with feces deposited in?
SOIL
TAENIA SOLIUM: LIFE CYCLE
MOT of pigs
ingestion of the embryonated egg
TAENIA SOLIUM: LIFE CYCLE
TOF. The egg hatches as it passes in the duodenum and jejunum of the pig.
T
TAENIA SOLIUM: LIFE CYCLE
What penetrates the wall of the intestine to enter the mesenteric venules
Released oncosphere
TAENIA SOLIUM: LIFE CYCLE
Released oncosphere penetrates the wall of the intestine to enter the mesenteric venules and carried throughout the body where it develops into the?
cysticercus cellulosae larvae
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
TOF. Taeniasis solium produces no serious damage or grave manifestation.
T
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
It may produce slight local inflammation of the intestinal mucosa due to mechanical irritation by the? (2)
strobila and the attached scolex
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
found in practically all organs and tissues of man and symptoms vary according to the number of the larva present as well as their location
Cysticercus cellulosae
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
Common locations of Cysticercus cellulosae
subcutaneous and intermuscular tissues
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
resemble small lipomas
Subcutaneous cysts
removed surgically usually for diagnostic purposes
Subcutaneous cysts
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
The larva provokes a typical sequence of local cellular reactions that include infiltration of?
five
neutrophils, eosinophils, lymphocytes, plasma cell, and giant cells
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
Cysticercosis may also involve the eyes, brain, liver, lungs, and abdominal cavity. Except in the?
Except in the eye, ventricles of the brain and subarachnoid spaces of the cranium and rachi, the cysticercus is surrounded with a fibrous capsule.
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
Cellular response is followed with?
fibrosis and necrosis
ibrosis and necrosis of the capsule with eventual caseation or calcification of the larvae
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
It usually involves the voluntary muscles and there may be?
myositis with fever and eosinophilia
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
non-encapsulated and may actively change shape with periodic extroversion and introversion of the scolex
Living cysticerci
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
involves the vitreous and anterior chamber of the eyes.
Ocular cysticercosis
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
TOF. Symptoms may consist of discomfort due to the shadow cast by the larva in front of the retina. Unless it is removed, it will eventually result to uveitis, iritis, retinitis, choroidal atrophy, palpebral conjunctivitis, or cyst formation depending on its location.
T
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
generally, well tolerated, and destroys the parasite to leave a calcified nodule
Cellular reaction
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
may experience intra-orbital pain, flashes of light, grotesque shapes in the visual field, and blurring and loss of vision
Ocular cysticercosis
TAENIA SOLIUM: TREATMENT
Prevention and Control
- Cooking and processing of pork
- Proper and thorough inspection of pork
- Environmental sanitation
- Complete and early treatment of infected individuals
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
most common manifestation
Convulsion
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
may also involve the bones, which may lead to fractures
Cysticerci
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
If the parasite dies, this develops that may endanger the eye
intense inflammation
TAENIA SOLIUM: CLINICAL MANIFESTATIONS
the larva may involve the cerebral cortex, meninges, ventricles, and, less often, the cerebral substance.
cerebral cysticercosis
TAENIA SOLIUM: LAB DIAGNOSIS
Demonstration
scolex with armed rostellum
- It produces taeniasis saginata or beef tapeworm infection
- a cosmopolitan distribution, and, in most places, its prevalence is greater than that of T. solium
TAENIA SAGINATA
TAENIA SOLIUM: LAB DIAGNOSIS
also helpful since the larvae in the tissues will show calcification
Radiologic examinations (CT scan, MRI)
TAENIA SOLIUM: LAB DIAGNOSIS
Taeniasis solium is diagnosed by identification of?
egg in feces
TAENIA SOLIUM: LAB DIAGNOSIS
Immunologic tests
LISA, Western blot, and IHA
TAENIA SOLIUM: LAB DIAGNOSIS
TOF. Recovery and identification of the gravid and/or mature segment is non-specific than identification of the eggs.
F (more spec)
TAENIA SOLIUM: LAB DIAGNOSIS
Recovery and identification
gravid and/or mature segment
TAENIA SOLIUM: LAB DIAGNOSIS
Diagnostic
cysticercosis inspection of a whitish or grayish mass seen in the anterior or vitreous chamber of the eye with impaired vision
ocular cysticercosis
TAENIA SOLIUM: TREATMENT
used for taeniasis solium
Praziquantel, Niclosamide, Albendazole, Mebendazole, Paromomycin
according sa lecture, tatlo lang
Praziquantel, Niclosamide, Albendazole,
TAENIA SOLIUM: TREATMENT
TOF. Taeniasis solium may be accompanied with cysticercosis due to internal autoinfection but pure cysticercosis cannot produce adult worm infection.
T
TAENIA SOLIUM: TREATMENT
Treatment for Larval infection
- Excision ASAP before it dies and tiggers an allergic reaction
- Praziquantel
TAENIA SAGINATA
Adults inhabit the
Small intestine
TAENIA SAGINATA
Adult worm measures?
more than 25 meters long (often 5 meters)
TAENIA SAGINATA
no. of proglottids
approximately 1000 to 2000
TAENIA SAGINATA
MOT to Man
ingests cysticercus bovis larva contained in raw or improperly cooked beef
TAENIA SAGINATA
Maturation
small intestine
TAENIA SAGINATA
Eggs escape from the gravid segments and are evacuated with the stool into the?
soil
TAENIA SAGINATA
MOT to cattles
Ingestion of mature egg contained in the stool in the soil
TAENIA SAGINATA
ingested by cattle and reaches the?
where it hatches to release the oncosphere
Duodenum
TAENIA SAGINATA
The oncosphere penetrates the intestinal wall, goes into the mesenteric venules or lymphatics, and is carried by the blood circulation into different sites of the cow’s body, although more commonly in striated muscles. The organisms transform into?
cysticercus bovis larva
TAENIA SAGINATA
TOF. Taeniasis saginata usually occurs with a single worm infection only.
T
TAENIA SAGINATA
TOF. There is no larval infection among humans.
T
TAENIA SAGINATA
Patients may complain of epigastric pain, vague abdominal discomfort, vertigo, nervousness, nausea and vomiting, and diarrhea.
wala skl
TAENIA SAGINATA
Individual proglottid may be lodged in the appendix causing
acute appendicitis
TAENIA SAGINATA
common complaints
discomfort and embarrassment due to the crawling segments
TAENIA SAGINATA: Diagnosis
- Indicate Taeniasis but impossible to diagnose the species
- May give higher recovery of eggs than examining the stool
- To differentiate between taenia saginata and taenia solium
A. Scotch tape technique
B. Identification of the egg
C. Demonstration of gravid proglottids
D. Demonstration of unarmed scolex
BAD
TAENIA SAGINATA:
Treatment and Control
- Treatment: Praziquantel & Mebendazole
- Prevention: Adequate treatment of patient; Personal hygiene and environmental sanitation; Proper inspection and cooking of beef; Thorough processing and cooking of beef
TAENIA SOLIUM or TAENIA SAGINATA
Roughly quadrate with 4 ventral/deep cup-like suckers
A conspicuous rounded provided with a double row of about 22 - 36 large and small hooks (armed scolex).
Scolex (solium)
TAENIA SOLIUM or TAENIA SAGINATA
Quadrate with 4 hemispherical suckers, apical region of which is somewhat concave and superficially pigmented.
Uterine pore seen laterally
There are no hooks (unarmed scolex).
Scolex (SAGINATA)
TAENIA SOLIUM or TAENIA SAGINATA
Somewhat rectangular-shaped, with a genital pore in one of the lateral sides.
There are two ovaries, no accessory ovarian lobe and 300 - 400 testicular follicles.
Mature segments (SAGINATA)
TAENIA SOLIUM or TAENIA SAGINATA
Ovary, in the posterior 3rd of the segment, consists of 2 large, symmetrical lobes and an accessory lobe on the side of the genital pore.
Testes consist of 150 - 200 follicles distributed at the dorsal plane.
Mature Segment (solium)
TAENIA SOLIUM or TAENIA SAGINATA
7 - 13 (usually 9) main lateral branches on each side of the main uterine trunk at the middle (diagnostic).
The terminal gravid proglottid becomes separated from the strobila and passes out in the feces or migrates down by itself towards the anus.
Gravid Segment (solium)
TAENIA SOLIUM or TAENIA SAGINATA
15 – 20 lateral branches on each side (diagnostic)
Other structures have atrophied due to the markedly enlarged uterus
There is a genital pore at the lateral margin
Gravid Segments (saginata)
TAENIA SOLIUM or TAENIA SAGINATA
31 - 43 um in diameter, yellowish – brown or pale buff to walnut-brown color.
truncated
Spherical or sub-spherical, with the thick eggshell consisting of many truncated prisms cemented together and provided with a thin hyaline embryonic membrane.
Contains a fully developed oncosphere with 3 pairs of hooklets.
Egg (solium)
TAENIA SOLIUM or TAENIA SAGINATA
5 – 8 x 10 mm, ovoid to spherical, with translucent cyst
The milky-white bladder worm has an opaque scolex that is invaginated into the bladder and the scolex has a circle of hooklets (armed) has 4 cup-like suckers.
Cysticercus cellulosae (larval stage) - solium
TAENIA SOLIUM or TAENIA SAGINATA
Cannot be distinguished from the egg of Taenia solium.
Egg (sagi)
TAENIA SOLIUM or TAENIA SAGINATA
7.5-10mmx4-6mm
Ovoid with unarmed scolex
Milky-white or opalescent in color
Larva (cysticercus bovis) - sagi