Exam 1 – Lecture 8: Connective Tissue 2 Flashcards
What are reticular fibers?
Support structure of various organs (especially hemopoeitic and lymphoid organs)
What kind of pattern do reticular fibers make?
Mesh-like (reticulated)
What are elastic fibers like?
Linear, stretchy, and coiled
What are elastic fibers made out of?
Elastin and fibrillin
What do elastic fibers make up?
Vertebral ligaments, larynx, elastic arteries
What is the extracellular matrix?
Everything outside of cells
What ground substance makes up the extracellular matrix?
Proteoglycans
Multi adhesive glycoproteins
Glycosaminoglycans
What does the extracellular matrix do?
Support and communications
What are the 2 types of connective tissue categories?
Loose
Dense
Describe loose connective tissue
Loosely arranged fibers
Abundant, various cell types
What are the 2 types of dense connective tissue?
Irregular and regular
Describe irregular dense connective tissue
Many fibers, few cells Lamina propria (beneath epithelia), matrix for blood vessels
Describe regular connective tissue
Ordered, densely packed fiber cells
What are the types of cells in connective tissue?
Fibroblast Macrophages Adipocytes Mast cells Transient WBCs
What is the main cell of connective tissue?
Fibroblast
What do fibroblasts produce?
Collagen
What is the mature cell type of fibroblasts?
Fibrocytes
What is a myofibroblast?
A fibroblast with muscle-type components
What are myofibroblasts a pat of?
Healing, allows scars to shrink
Describe macrophages
Resident phagocytes
Large, 25-30 microns
“Bean-shaped” nucleus
Abundant amphiphilic cytoplasm
Describe mast cells/basophils
Rare, discrete cells
Prominent basophilic granules
Bone marrow origin
Where do you tend to find mast cells/basophils?
Skin, mucous membranes in allergic organs
What do mast cells/basophils produce?
Vasoactive substances
What vasoactive substance do mast cells/basophils produce?
Histamine
Heparin
Leukotrienes
Eosinophil chemotactic factor
What do adipocytes do?
Energy storage
Where are adipocytes located?
Subcutaneous, internal organs