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SP14 Microbiology > EX1 Antigen Processing/Presentation - Stiner > Flashcards

EX1 Antigen Processing/Presentation - Stiner Flashcards

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Biology 101 flashcards
1
Q

CD8 cells recognize MHC class (I or II)

A

MHC class I

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2
Q

CD4 cells recognize MHC class (I or II)

A

MHC class II

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3
Q

______ _____ is the bridge between antigen recognition and the ignition of a full-blown immune response

A

antigen presentation

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4
Q

Antigen presentation enables T cell-mediated _______ or augments antibody production by ______

A

killing

B cells

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5
Q

Antigen presentation is ______ ______, allowing the deployments of appropriate immune responses under different conditions

A

context dependent

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6
Q

Antigen recognition without antigen presentation can result in ________, this minimize the chances of _________ activity

A

tolerance

autoimmune

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7
Q

Antigen presentation is modulated by _______ _______

A

co-stimulatory molecules

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8
Q

Successful antigen presentation results in activation of _______

A

T cells

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9
Q

What are the three main antigen presenting cells (APCs)

A

dendritic cels
macrophages
B cells

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10
Q

All nucleated cells can present endogenous antigens in association with MHC class (I or II) molecules

A

MHC class I

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11
Q

Pathway 1 of antigen processing involves (endogenous/exogenous) antigens

A

exogenous

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12
Q

Pathway 2 of antigen processing involves (endogenous/exogenous) antigens

A

endogenous

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13
Q

In this pathway of antigen processing the antigens are digested to small peptides and presented to CD8 cells via MHC class I; uses ubiquitin

A

Pathway 2 (cytosolic pathway)

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14
Q

In this pathway of antigen processing the antigens are taken into the cell, small peptides are generated and presented to CD4 cells via MHC class II

A

Pathway 1 (endocytic pathway)

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15
Q

The processes by which antigens are digested and placed on the cell surface with correct MHC molecules

A

antigen processing

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16
Q

The invariant chain/CLIP of MHC class II processing does what?

A

keeps the MHC from binding with anything while it is forming/traveling

17
Q

Both class I and class II MHCs are formed in the ______

A

rough endoplasmic reticulum (RER)

18
Q

MHC class (I or II) makes use of an endocytic compartment containing the antigen to be presented

A

MHC class II

19
Q

MHC class (I or II) contains α1, α2, α3, and a β2 component

A

MHC class I

20
Q

MHC class (I or II) contains an α1, α2, β1, and a β2 component

A

MHC class II

21
Q

MHC haplotypes can influence three things like…

A

how an individual responds to certain pathogens
susceptibility to certain diseases
transplant success

22
Q

True or False

MHC genes are highly polymorphic

A

True; roughly 10^13 different combinations; the alleles are co-dominantly expressed

23
Q

True or False

MHC molecules have a broad specificity for peptides

A

True; many different peptides can bind within MHC binding clefts

24
Q

True or False

Peptides associated with MHC have a rapid on and rapid off rate

A

False; they have a slow on and off rate

25
Q

True or False

MHC molecules do discriminate from self and foreign peptides

A

False; they do not discriminate

26
Q

MHC ________ allows individual T cells to recognize foreign antigens displayed on the surface on an individual APC; allowing recognition of self or non-slef

A

MHC restriction

27
Q

True or False
In order for the antigen to be properly presented the T-cell receptor (TCR) must engage the MHC molecule and other co-stimulatory molecules

A

True

28
Q

The main secondary signals of MHC/TCR recognition are ______ and _____

A

CD28 (on T cell)

B7 (on APC)

29
Q

Which T cell recognizes cytosolic proteins

A

CD8

30
Q

Which T cell recognizes extracellular/intravascular pathogens

A

CD4

31
Q

____ and ____ are non-covalently associated to the TCR and they are required for antigen recognition and signaling

A

CD3 and ζ (zeta)

32
Q

_______ competitively binds to B7; blocking signals from the TCR

A

CTLA-4

33
Q

True or False

You must have both the MHC and co-stimuntory molecule in orderer for the T cell to be activated

A

True

34
Q

What interleukin drives the development of Th1 cells

A

IL-12

35
Q

What interleukin drives the development of Th2 cells

A

IL-4

36
Q

Th (1 or 2) cells provide help for cell mediated immune responses

A

Th1

37
Q

This is an important Th1 cytokine

A

IFN-γ

38
Q

Th (1 or 2) cells provide help for humoral immune responses

A

Th2

39
Q

This is an important Th2 cytokine

A

IL-4

SP14 Microbiology (31 decks)

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