Chronic inflammation Flashcards
What is chronic inflammation
inflammation in which the cell population is especially lymphocytes, plasma cells and macrophages. features of tissue of organ damage- loss of function. tends to be long term. can be primary pathology
What are clinic findings in chronic inflammation
no specific sore bit, malaise and weight loss, loss of function of tissue
what are causes and components of chronic inflammation?
developed from acute- large volume of damage, inability to remove debris, failure to resolve, ongoing acute insult
primary- autoimmune disease, material resistant to digestion, exogenous substances, endogenous substances, granulomatous inflammation
What are the outcomes of chronic inflammation?
ongoing tissue damage and destruction, insidious loss of function, cellular and stromal response (granulation tissue, angiogenesis), fibrosis and scarring, granuloma formation
granulation tissue mechanism and function
plasma proteins and macrophages access inflammatory mass, fibroblasts lay down collagen and collagen replaces inflammatory tissue- scar. it patches tissue defects, replaces dead or necrotic tissue and contracts and pulls together
angiogenesis occurs in
thrombosis- limits thrombus proagation, reinstates flow.
malignant tumours- as tumor grows it occurs, potential for therapeutic control
angiogenesis occurs in
thrombosis- limits thrombus propagation, reinstates flow.
malignant tumours- as tumour grows it occurs, potential for therapeutic control
What is granulomatous inflammation?
presence of granulomas in tissues and organs. stimulated by indigestible antigens and it causes serious infectious and idiopathic diseases
What is wound healing?
process of repair of tissue damage. phase of acute inflammation, granulation tissue formation, local angiogenesis, fibrosis and scar formation
What is fracture healing?
process of repair of bone tissue damage. have to repair bony structure as well as soft tissue surrounding it. granulation tissue plus osteoblasts are used.
granulomas
response to indigestible antigens. clusters of macrophages in tissue. may contain giant cells or be surrounded by dead material or lymphocytes. many are type IV hypersensitivity reactions
infective granulomas
syphilis, tuberculosis, leprosy
non infective granulomas
rheumatoid disease, sarcoidosis, crohns disease
