cancer genetics

Question 1

cancer can be caused by what kinds of mutation

Answer 1

somatic or germline

Question 2

genetic processes associated with cancer

Answer 2

oncogenes, tumor suppressor genes, DNA damage response genes

Question 3

oncogenes

Answer 3

accelerate cell division. mutated protooncogene eg multiple endocrine neoplasia

Question 4

tumor suppressor genes only happen after

Answer 4

second hit. 1st hit are susceptible carriers eg breast or ovarian cancer

Question 5

DNA damage response gene mutation leads to

Answer 5

mismatch repair failure which leads to micro satellite instability (genetic predisposition to mutation) eg Lynch syndrome, colorectal cancer