Chapter 7: Tolerance Flashcards
0
Q
Chronic Tolerance ?
A
with repeated administration BDZs have less effective ability to modulate GABA
-develops slowly to anticonvulsants
1
Q
Acute tolerance?varies on the drug being tested and the effect measured
A
- limited to humans
- BDZs …….digit symbol substitution and tracking behaviour…
- can develop also to motor impairing of midazolam
- phenobarbital has a more powerful effect when BLVL is rising than when its descending..
2
Q
Cross tolerance
A
seen btwn BZDs and other depressants
-drowsiness produced via doses of BZD is less often in those with recent history of BARBs and Alcohol abuse…
3
Q
Tolerance to BZDs and BARBs could be
A
similar in mechanisms…
