Chapter 15: Anesthetic Hallucinogens (Dissociative Anesthetics)

Question 0

Phencyclidine (PCP)

1. Used in what kind of medicine as an anesthetic/analgesic
2. Difference between it and other anesthetics?
3. Produces some symptoms of what disorders?

Answer 0

1. veterinary
2. no significant depression of respiration or bp
3. schizophrenia, mania, and depression may persist post drug as well

Question 1

What do they block in terms of receptors?What does it interfere with?

Answer 1

• NMDA receptors for glutamate and aspartate (primary excitatory NTs)
• interferes with memory formation

Question 2

Phencyclidine (PCP)

1. Some users exhibit ___ and other __ behaviour but PCP ___ generate this.
2. Users can show ___ behaviour and ___.
3. What are some characteristic effects of PCP?

Answer 2

1. violence, antisocial, does not
2. unpredictable, suspicion
3. Distortions of body image (rubber doll effect), dissociation (out of body) and a floating sensation
   4

Question 3

Phencyclidine (PCP)

1. Can users be talked down from a bad trip?
2. Does tolerance develop? vs LSD?
3. what kind of hallucinations are experienced after anesthetic effects?
4. Self administration?

Answer 3

1. NOOOOO ; confine them to a dark and quiet room alone
2. Yes but much slower than LSD
3. post-anesthetic hallucinations (emergence delirium)
4. In both animals and humans it is seen

Question 4

Ketamine:

1. It is a ____ anesthetic used in ___ medicine. It’s also considered a __ drug and __ drug.
2. Causes what sense of effect?
3. It is __ potent in comparison to PCP with a ____ duration of action and ___ emergence effects.

Answer 4

1. general, veterinary, club, date-rape
2. floating and dissociation
3. more, shorter, milder

Question 5

Ketamine:

1. Physical description
2. Recently has been approved for treating what in 2013?

Answer 5

1. colourless, tasteless in liquid form; liquid can be heated to a power and snorted.
2. depression

Question 6

Withdrawal for either??

Answer 6

• yes

- vocalizations, grinding of teeth, diarrhea, difficulty staying awake, anxiety confusion and tremors.