Chapter 6: Harmful Effects of Chronic Ethanol

Question 0

Wernicke-Korsakoff Syndrome?

Answer 0

loss of memory, for past events, inability to remember new material, disorientation and confusion.

• deficiency in thiamin (vitamin B1)
• digestive tract distruction

Question 1

Nervous system ?

2

Answer 1

1. Wernicke-Korsakoff Syndrome

2. Neuronal and glial cell loss

Question 2

Other disorders?

Answer 2

epilepsy, cerebelar syndrome, alcoholic dementia

Question 3

MRI’s show there is a _______ in cerebral blood flow and widespread _____ in brain tissue including loss of glial cells and neurons in the _____,____,____, and _____.

Answer 3

• decrease
• reduction
• prefrontal cortex, hypothalamus, cerebellum, and hippocampus.

Question 4

Neurodegeneration ? 
-during? 
-glutamate?? 
-alcohol protection?
duration before symptoms?

Answer 4

during intoxication, increase in oxidative stress and proinflammatory proteins which are neurotoxic…..

• glutamate excitotoxicity …high lvls call cell death….
• alcohol can protect us from Glutamate issues via blocking NMDA receptors but frequent use causes upregulation of glutamate transmission and excessive glutamine release during hangover and withdrawal.
• many years!!