Chapter 7: History of Development

Question 0

Chlorodiaxepoxide (librium) the first benzodiazepine (BDZ) was discovered in ____ by the 1990s the BDZ has largely replaced the BARBs except for ____.

Answer 0

1957, treatment of epilepsy.

Question 1

First Barbiturate synthesized in _____, the only drugs used as sedatives and anxiolytics from ____-____.

Answer 1

1864, 1920-1950

Question 2

Benzodiazepines differ from one another in terms of duration of ___ and ___.

Answer 2

action, potency

Question 3

Flunitrazepam (Rohylpnol) because of its ____ property became a notorious date rape drug.

Answer 3

-amnesic property

Question 4

Other drugs recently found to have anxiolytic properties: 
1. 
2. different life time as the doctor
3. Buspirone (Buspar) : Receptor agonist
b
c

Answer 4

1. Antipsychotics (too many side effects)
2. Antidepressants
   a. narrow therapeutic window
   b. no sedation or more muscle movement
   c. delayed effect.