Chapter 3 Flashcards
What is the nervous system thought of as
The major controlling and communicating system of the body
Goal of neuroscience
To understand the nervous system: how it develops and changes and how it’s affected by various drugs and diseases
What are neurons?
Assembly of interconnected cells that form a complex web of connections that pulse with electrical and chemical energy and are used for receiving, processing and communicating information
What 4 characteristics allow the brain and the rest of the nervous system to command behaviour
Complexity, adaptability, integration and electrochemical transmission
Define synapses
Tiny spaces between neurons where the gaps are referred to as synaptic gaps or clefts . Used for neuron to neuron connection
Define the connectome project
A term coined in reference to the genome and aims to create a highly detailed map of all the connections of a nervous system across several species
How are neurons integrated in our daily lives through their structural arrangements and patterns of activity?
The structural arrangements of connections among neurons are your memories whereas the pattern of activity among neurons serve as the basis of your consciousness, emotions, personality and more
Define integration
The brain receives information through multiple sources, analyzes the information and releases a response. Does it by extracting patterns of incoming data and using past experiences, your knowledge and current emotions to integrate
Why is the brain considered the ultimate organ of adaptability?
Due to its ability to change and reorganize itself throughout a person’s life
What is neuroplasticity?
A process that allows the brain to constantly adjust to new experiences and form new neural connections which can lead to improved function
Define hippocampus
The structure in the limbic system that has a special role in the storage of memories
Define acquired savant syndrome
Individuals gaining special skills or talents after suffering brain injury or disease
What is electrochemical transmission?
Information processing system powered by electrical impulses and chemical messengers
An impulse travels down a neuron electrically and communicates with the next neuron using chemicals
Define afferent (sensory) nerves
Carry information from sensory receptors to the brain and spinal cord. Pathways communicate information about the external environment (phone vibrations) and internal conditions (hunger)
Define efferent (motor) nerves
Communicate information from the brain and spinal cord to the other areas of the body such as muscles and glands
What are the 2 primary divisions of the human nervous system?
Central nervous system and peripheral nervous system
What are the components of the central nervous system
Spinal cord
Brain
- Hindbrain: cerebellum, medulla, pons
- Midbrain: reticular formation
- forebrain: limbic system, hypothalamus, cerebral cortex, basal ganglia
What are the components of the peripheral nervous system?
Somatic nervous system
- sensory nerves
- Motor nerves
Autonomic nervous system
- parasympathetic branch: calms the body
- sympathetic branch: arouses the body
What does the somatic nervous system control?
Sensory and motor neurons
What does the autonomic nervous system control?
Monitors organs for processes such as breathing, heart rate and digestion
Define the peripheral nervous system
Network of nerves that connects the brain and spinal cord to other parts of the body and its function is to bring information to and from the brain and spinal cord
Which nervous system is involved in the fight or flight response
The sympathetic nervous system
Which nervous system is associated with the “rest and digest” response
Parasympathetic nervous system
In an emergency, what does the sympathetic nervous system do?
Trigger the body’s release of powerful hormones such as stress hormones that allow you to focus all your attention on what needs to be done at the current moment
The average volume of the human brain is roughly
1300 cubic centimetres
2 major classes of cells in the nervous system
The neuron and the glial cell
How are glial cells critical to brain function
Provide support, nutritional benefits, protection. Help neurons run faster and more efficiently
The “glue” that holds the nervous system together
What brain disorders may glial cells play a critical role in if they don’t function properly?
Alzheimer’s disease, chronic pain, epilepsy
What are the 5 common features of a neuron
Cell body
Dendrites
Axon
Axon terminals
Cell membrane
Function of a cell body in a neuron
Metabolic and genetic hub of the neuron
Contains machinery necessary for maintaining neuron function such as enzymes and structural proteins
Houses the nucleus which contains sequences of DNA that determine structural and functional properties of neurons
What factors can impair the ability to form and store new memories?
Sleep deprivation, stress, alcohol consumption and more
Define dendrites
Branchlike fibres projecting from a neuron which receive information and orient it towards the neuron’s cell body
What do dendrites increase?
Surface area of the neuron which provides multiple sites for synaptic contact
What neuro developmental disorders are associated with alterations in dendrite shape, size and number
Down syndrome, Alzheimer’s disease, schizophrenia, autism spectrum disorder
Define axon
The part of the neuron that carries information away from the cell body toward other cells
Define action potential
The brief wave of positive electrical charge that sweeps down the axon
What does the axon use for transmission of information?
Action potentials
Define synaptic boutons
Small, bulb shaped structures at the end of an axon where chemicals are stored and released to affect the functioning of neighbouring neurons
Define cell membrane
A thin specialized boundary that maintains the cell’s integrity
Define myelin sheaths
Speed up transmission of nerve impulses by insulating axons
Why is the cell membrane necessary?
Serves as a barrier between the interior and surrounding environment
What are ions?
Particles that come from atoms that have either gained (negatively charged) or lost (positively charged) one or more electrons
Which ions carry positive charges and which carry negative charges?
Sodium and potassium carry positive charged while chloride is negatively charged
Describe the movement of ions?
Since ions and other molecules are distributed unevenly throughout the membrane, they will want to move from areas of high concentration to areas of low concentration. This process is called diffusion
Describe the movement of ions?
Since ions and other molecules are distributed unevenly throughout the membrane, they will want to move from areas of high concentration to areas of low concentration. This process is called diffusion
Define selective permeability
The membrane selectively allows certain molecules and ions to pass while restricting the movement of others
When the neuron is not transmitting information….
It is in resting state
Due to separation of ions across the membrane, the cell is said to be
Electrically polarized
Define resting potential
The stable, negative charge of an inactive neuron
What produces a neuron’s resting potential?
When the fluid outside the neuron is rich in sodium ions but low in potassium whereas the fluid inside the neuron is high in potassium and low in sodium. At rest, the neuron is more selectively permeable to potassium allowing it to flow out and also slightly permeable to sodium allowing it to flow in
How does the sodium potassium pump maintain proper ion concentrations
Pump moves in 2K+ ions while ejecting 3 Na+ ions
Define neurotransmitters
Chemical messengers (molecules) released into the synapses that allow the nervous system to send messages between neurons or from neurons to muscles
What is the voltage of the axon membrane at rest
-70 mV
How is the action potential triggered?
Neurons can either release excitatory or inhibitory inputs, if the sum of excitatory inputs exceeds the sum of inhibitory inputs, the axon might be sufficient to change its resting potential and generate an action potential
Define depolarization
When the axon becomes more positive and is reduced to a less negative value of around -50mV. If resting potential was -70, the axon must be depolarizer by at least 20mV
Define axon hillock
The spot where the action potential is generated and has a higher concentration of Na+ and K+ channels than anywhere else
What causes electrical changes??
The movements of sodium and potassium ions into and out of the axon
Define refractory period
“Time out” - ensures that a neuron is not generating another action potential too quickly
Summarize the electrical activity of neurons
- Resting potential: maintains a small negative change of -70mV
- Action potential: when the neuron is stimulated by the release of neurotransmitters, it fires allowing the channels to open and sodium to rush in resulting in a positive charge
- Refractory period: sodium ions exit until it reaches resting potential