Chapter 21 Flashcards
drugs
substances used to prevent or treat disease or condition
synthesized
made in a laboratory
vitamins
drugs that are isolated from plant and animal sources and are contained in food
pharmacist
prepares and dispenses drugs
pharmacy
drug store
prescription
order for drugs
pharmacy technician
helps pharmacist provide medication and other health care products to patients
pharmacology
study of the discovery, properties, uses of drugs
pharmacologist
MD or PhD who specializes in study of medicines
subdivisions of Pharmacology
- medicinal chemistry
- pharmacodynamics
- pharmacokinetics
- molecular pharmacology
- chemotherapy
- toxicology
medicinal chemistry
study of new drug synthesis and relationship between chemical structure and biological effects
pharmacodynamics
study of drug’s effect on its target in the body
pharmacokinetics
study of drug absorption, distributions into body compartments, metabolism, and excretion
molecular pharmacology
interaction of drugs and subcellular entities
chemotherapy
study of drugs that destroy microorganism, parasites, or malignant cells in the body
toxicology
study of harmful effects of drugs and chemical in the body
antidote
substance that prevent or reverse the unwanted effects of drugs
chemical name
exact chemical makeup of the drug
generic name
identifies the drug legally and scientifically
brand name
trademark is private property of the individual drug manufacturer
Food and Drug Administration (FDA)
government agency having legal responsibility for enforcing proper drug manufacture and clinical use
United State Pharmacopeia
reviews the available commercial drugs and continually reappraises their effectiveness in specific medical conditions
hospital formulary
gives up to date info about characteristics of drugs and their clinical usage as approved by that particular hospital
Physicians’ Desk Reference
reference book that lists drug products
oral administration
given by mouth
sublingual administration
drug placed on tongue to dissolve in saliva
rectal administration
suppositories(cone shaped) and aqueous solutions are inserted into the rectum
parenteral administration
injection of a drug from a syringe
- under skin, into muscle, vein, or body cavity
pleurodesis
obliterating the pleural space and preventing accumulation of fluid
intradermal injection
injection into upper layers of skin
- tests for allergic reactions
subcutaneous (hypodermic) injection (subQ)
small hypodermic needle into the subcutaneous tissue under skin
- upper arm, thigh, abdomen
-ex: insulin
intramuscular injection (IM)
shot in the buttock or upper arm into the muscle
- rapid absorption of single dose
intrathecal instillation
into the space under the membranes (meninges) surrounding spinal cord and brain
intravenous injection
injection in the vein
inhalation
vapors or gases taken into the nose or mouth
aerosols
particles of drug suspended in air via inhalation
topical application
applied locally on skin or mucous membrane
antiseptics
against infection
antipruritics
against itching
transdermal patch
used to deliver drugs continuously through the skin
receptor
specific target
dose
amount of drug administered
- usually in grams or milligrams
schedule
exact timing and frequency of drug administration
additive action
when two similar drugs is equal to the sum of the effects of each
antagonistic effect
two drugs give less than additive effect
synergistic effect
when two drugs produce greater than the sum of the individual effects
response
desired and beneficial effect of a drug
tolerance
larger and larger drug doses must be given to achieve desired effect
addiction
physical and psychological dependence for a drug and presence of clearly unpleasant effects when that drug is stopped
dependence
physiological needs for a drug with prolonged use
controlled substance
drugs that produce dependence and have potential for abuse and addiction
idiosyncrasy
any unexpected and uncommon side effect that develops after administration of a drg
anaphylaxis
acute hypersensitivity with asthma and shock
iatrogenic
produced by treatment
iatrogenic reaction
disorders can occur however as a result of mistakes in drug use or because of individual sensitivity to a given agent
side effects
unpleasant effects that routinely result from the drug use
conraindications
drug resistance
loss of effectiveness of a drug
analgesic
lessens pain
- high end narcotics and opiods
nonsteroid anti-inflammatory drugs (NSAIDs)
example cortisone
anesthetics
eliminates sensations
general anesthetic
whole body
local/ regional anesthetic
limited to a particular region
antimicrobial drugs
kill or inhibit the growth of microorganism (bacteria, viruses, fungi, an protozoans)
antibiotice
chemical agents made from molds and bacteria that inhibit or kill bacteria
antibacterial drugs
interfere with the growth and reproduction of bacteria
antitubercular drugs
treat tuberculosis
antifungals
treat fungal infections
antiviral
used against infections due to viruses
- like flu, herpes, cytomegalovirus
antiprotozoans
act against infections caused by protozoans that become parasites in humans
anticoagulants
prevent clotting of blood
- heparin and warfarin (coumadin)
heparin
natural anticoagulant purified from pig intestine or cow lung
International normalized ratio test
measures blood clotting time and is kept in a safe range of 2.0-3.0
tissue type plasminogen activator (tPA)
dissolves clots and is used to open vessels after myocardial infarction
Direct acting oral anticoagulants (DOACS)
direct acting oral coagulant that reduces risk of stroke
antiplatelet drugs
reduce tendency of platelets to stick together
anticonvulsant
prevents and reduces frequency of convulsions in seizure or epilepsy
antidepressants
treat symptoms of depression
examples of antidepressants
- tricyclic antidepressants (TCA)
- selective reuptake inhibitors (SSRIs)
- monoamine oxidase inhibitors (MAOIs)
anti-alzheimer drugs
treats symptoms of Alzheimers disease
- adis brain neurotransmitters or sheilding brain cells from glutamate (leads to dead brain cells)
antidiabetics
used to treat diabetes ( insulin is not produced or insensitivity to insulin)
biguanides
increase insulin, reduce glucose by liver
alpha glucosidase inhibitors
temp block enzymes that digest sugars
thiazolidinediones
enhance glucose uptake into tissues
DPP4 inhibitors
inhibiting enzymes so that cells make more insulin when glucose levels are high
SGLT2 inhibitors
body to excrete glucose in urine
non-insulin injectable medications
stim cells in pancreas to make and release insulin
antihistamines
blocks histamine (allergic reactions)
anaphylactic shock
dyspnea, hypotension, loss of consciousness
antiemetic
prevention of nausea
osteoporosis
loss of bone density
antiosteoporosis drugs
biphosphonates (prevent bone loss) and selective estrogen receptor modulators (increase bone formation)
cardiovascular drugs
act on heart or blood vessels to treat hypertension, angina, mycardial infarction, congestive heart failure, and arrhythmias
digoxin
helps heart pump more forcefully in heart failure
angiotensin converting enzyme (ACE) inhibitors
dilate blood vessels to lower blood pressure, improve performance of heart, and reduce workload
angiotensin II receptor blockers
lowers blood pressure by preventing angiotensin from acting on receptors in blood vessels
antiarrhythmics
treats abnormal heart rhythms
beta blockers
slow heart rate, decrease heart output, and reduce BP by blocking the action of epinephrine in the heart muscle and blood vessels
calcium channel blockers
dilate blood vessels and lower BP
- used to treat arrhythmias
cardiac glycosides
drug increase the force of contraction of the heart and are used to treat heart failure and atrial fibrillation
- made from foxglove plant
cholesterol binding drugs
bind to dietary cholesterol and prevent uptake from the GI tract
cholesterol lowering drugs
statins block the formation of cholestrol in liver and treats hypercholesterolemia ( high levels in the blood)
diuretics
reduce blood volume by promoting kidney to remove water and salt through urine
androgens
male hormones
antiandrogens
interfere with production of androgens or with their binding tissues
- useful against prostate cancer
estrogens
female hormones
aromatase inhibitors
reduces the amount of estrogen in the blood and are effective against breast cancer
selective estrogen receptor modulators (SERMs)
estrogen like effects on bone (increase bone density) and lipid metabolism (decrease cholesterol levels)
progestins
treats abnormal uterine bleeding caused by hormonal imbalance
thyroid hormone
given when there is a low output of hormone from thyroid gland
calcitonin
used to treat osteoporosis
- thyroid hormone
glucocorticoids
reduce inflammation and wide range of other disorders
parathyroid hormone
stimulates new bone formation
growth hormone release inhibiting factor (somatostatin)
treats GI symptoms associated with acromegaly
antacids
neutralize hydrochloric acid in stomach to relieve symptoms of peptic ulcer, esophagitis, and reflux
antiulcer
block secretion of acid by cells in the lining of the stomach and presrcibed for patients with gastric and duodenal ulcers and GERD
cimetidine (tagamet)
turn off histamine and promotes secretion of stomach acid
omeprazole (prilosec)
stops acid production by proton pump inhibition
anitdiarrheal
relieve diarrhea and decrease rapid movement (peristalsis) in muscular wall of colon
cathartics
relieve constipation and promotes defecation
laxative
mild cathartics
purgative
stron cathartics
antinauseants (antiemetics)
relieve nausea and vomiting and overcome vertigo, dizziness, motion sickness, and similar symptoms
Anti TNF (tumor necrosis factor)
used to treat autoimmune disease
-like Crohn’s
bronchodilators
open bronchial tubes
- administered by injection or aerosol inhaler
steroid drugs
inhaled or given intravenously and orally to reduce chronic inflammation in respirator passageway
leukotriene modifiers
prevent asthma attacks and bronchospasms by blocking leukotriene from binding to receptors in respiratory tissue
sedative
depress CNS and promotes drowsiness
- barbiturates and benzodiazepines
benzodiazepines
may act as sedatives or hypnotics
amphetamines
used to prevent narcolepsy, suppress appetite, and calm hyperkinetic kids
caffeine
cerebral stimulant
tranquilizers
controls anxiety
minor traquilizers
benzodiazepines
major tranquilizers
phenothiazines