Chapter 12 and 14 : White Blood Cells and Platelets Flashcards
What are Leukocytes
Blood cells specialized to fight infections
The 2 types of leukocytes
Granulocytes and Argranulocytes
What is a Granulocyte
Granulated cytoplasm, ive about 12 hours
What is a Neutrophil
54-62% of WBC, Phagocytize small particles, mobile, arrive 1st to an injury
What is Eosinophil
2-4% of WBC, phagocytize parasites, debris, and control inflammation by removing irritants (parasites and allergens)
What is Basophil
less than 1% of WBC, release heparin (anticoagulent - that keeps blood from clotting) and histamine (increases blood flow to injured tissue = inflammation)
What is heparin
anticoagulent - that keeps blood from clotting
What is histamine
increases blood flow to injured tissue = inflammation
What are agranulocytes
Non-granulated cytoplasm, live anywhere from few days to a lifetime
Types of granulocytes
Neutrophil
Eosinophil
Basophil
Types of agranulocytes
Monocyte
Lymphocyte
What are Monoctyes
3-9% of WBC, phagocytize large particles, live weeks/months
When monoctyes enter tissues to fight infection they are called
Macrophages
What are Lymphocytes
25-33% of WBC, immunity protection (lie dormant until contact with specific infectious agent) i.e. tetanus, measles, chicken pox, then begin releasing specific antibodies to destroy the infectious agent
Agranulocyte (B cells)
Produced in bone marrow
Agranulocyte (T cells)
Produced by thymus gland (destroyed by AIDS virus)
Platelets
also known as Thrombocytes, small fragments of a megakaryocyte cell formed in red bone marrow
Platelets are capable of
amoeboid movement
Platelets (Physically)
Lack a nucleus, 1/2 the size of a RBC, live about 10 days
Platelets (Function)
To close small breaks in blood vessels and initiate coagulation by releasing prothrombin activator
Coagulation
Clotting
Hemostasis
Stoppage of bleeding
Hemostasis Phase 1 - Platelet Plug Formation Phase
- Prothrombin activator is released by platelets
- Ca+, Vitamin K, tissue factors, PF3 and Prothrombin activator combine to convert prothrombin into thrombin
Difference between prothrombin and thrombin
thrombin is the active form of prothrombin
Hemostasis Phase 2 - Vasospasm
- Damage to the blood vessel
- Serotonin is released to constrict walls of the vessel
Hemostasis Phase 3 - Coagulation
Thrombin converts dormant fibrinogen into fibrin
Fibrin forms a web that begins catching blood cells eventually forming a clot that will stop blood flow to that area