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Histology > Blood and Hemopoiesis Part II > Flashcards

Blood and Hemopoiesis Part II Flashcards

1
Q

Large protein composed of four polypeptide chains, each is bound to heme group (iron-containing)

A

HEMOGLOBIN

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2
Q

_____ moiety is responsible for releasing CO2

A

Globin

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3
Q

R state and T state

A

HEMOGLOBIN

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4
Q

Hb carrying 2,3-DPG

A

Deoxyhemoglobin

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5
Q

Hb carrying O2

A

Oxyhemoglobin

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6
Q

Hb carrying CO2

A

Carbaminohemoglobin

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7
Q

Human polypeptide chain of Hemoglobin

A

α, β, γ, δ

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8
Q

Human polypeptide chain of Hemoglobin:

A

HbF (α2, γ2)
HbA1 (α2, β2)
HbA2 (α2, δ2)

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9
Q

In adult, ___ HbA1, ___ HbA2, ____ HbF

A

96%, 2%, 2%

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10
Q

Much smaller than that of RBCs in number

A

LEUKOCYTES

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11
Q

4,000-11,000/cumm

A

LEUKOCYTES

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12
Q

when leukocytes leave the bloodstream by migrating between endothelial cells of the blood vessels

A

Diapedesis

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13
Q

Both have azurophilic granules (lysosomes)

A

Granulocytes
Agranulocytes

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14
Q

GRANULOCYTES:

A

NEUTROPHIL
EOSINOPHIL
BASOPHIL

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15
Q

Formation of the granulocytes (NEB) under the influence of several cytokines, GCSF, GM-CSF, IL-1, IL-5, IL-6, TNF-alpha,

A

GRANULOCYTOPIESIS

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16
Q

Descendant of CFU-GEMM to CFU-Eo (Eosinophil) and CFU-Ba (basophil) forming myeloblast as precursor cell

A

GRANULOCYTOPIESIS

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17
Q

Neutrophil arise from CFU-GM to CFU-G forming myeloblast

A

GRANULOCYTOPIESIS

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18
Q

Also known as Polymorphonuclear leukocytes

A

NEUTROPHIL

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19
Q

The most abundant of all WBCs (60-70%)

A

NEUTROPHIL

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20
Q

Multilobed nucleus

A

NEUTROPHIL

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21
Q

In females, the nucleus presents a characteristic small appendages, the “drumstick” which contains the inactive x chromosome

A

NEUTROPHIL

22
Q

One of the first cells to appear during acute bacterial infection

A

NEUTROPHIL

23
Q

Phagocytose and destroy bacteria using the contents of their granules

A

NEUTROPHIL

24
Q

contain various enzymes and pharmacological agents in performing antimicrobial function

A

Specific granules

25
Q

are lysosomes containing acid hydrolases, MPO, BPI protein, antibacterial agent lysozyme, etc

A

Azurophilic granules

26
Q

gelatinase and cathepsins inserted into plasmalemma

A

Tertiary granules

27
Q

NEUTROPHILIC GRANULES:

A

Specific granules
Azurophilic granules
Tertiary granules

28
Q

Constitutes less than 4%of the total WBCs

A

EOSINOPHILS

29
Q

Sausage-shaped, bilobed nucleus

A

EOSINOPHILS

30
Q

Helps to eliminate antigen-antibody complexes and destroy parasitic worms

A

EOSINOPHILS

31
Q

EOSINOPHILS GRANULES:

contains crystal-like center called internum, and surrounded by externum

32
Q

EOSINOPHILS GRANULES:

Internum: major basic protein, eosinophilic cationic protein, eosinophil-derived neurotoin

33
Q

EOSINOPHILS GRANULES:

lysosomes

A

Azurophilic granules

34
Q

The same function with mast cells but different origin (initiators of inflammatory process)

35
Q

Constitute less than 1% of the WBC population

36
Q

S-shaped nucleus but is commonly masked by the large specific granules

37
Q

BASOPHILS GRANULES:

stain dark blue to black pressed against the periphery (roughened perimeter)

A

Specific granules

38
Q

BASOPHILS GRANULES:

lysosomes

A

Azurophilic granules

39
Q

AGRANULOCYTES:

A

MONOCYTES
LYMPHOCYTES

40
Q

Share bipotential cell with neutrophil CFU-GM

A

MONOCYTOPOIESIS

41
Q

CFU-M arises after the mitosis of CFU-GM forming monoblast

A

MONOCYTOPOIESIS

42
Q

The largest of the circulating blood cells, enter the connective tissue spaces, where they are known as macrophages

43
Q

Constitute 3-8% of the WBC population

44
Q

Large, eccentric, kidney-shaped nucleus

45
Q

Cytoplasm is bluish with numerous azurophilic granules (lysosomes)

46
Q

FUNCTION: inflammatory and immune response

47
Q

LYMPHOPOIESIS:

A

T LYMPHOCYTE
B LYMPHOCYTE

48
Q

stem cell which give rise to immunocompetent B lymphocytesepressing special surface markers including antibodies

49
Q

cells undergo mitosis forming immunocompetent T cells

50
Q

Occurs in the bone marrow

51
Q

Occurs in the cortex of the thymus (maturation)

52
Q

Lymphoid Organs:

A

Spleen
Lymph nodes

Histology (37 decks)

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