Blood and Hemopoiesis Part II

Question 1

Large protein composed of four polypeptide chains, each is bound to heme group (iron-containing)

Answer 1

HEMOGLOBIN

Question 2

_____ moiety is responsible for releasing CO2

Answer 2

Globin

Question 3

R state and T state

Answer 3

HEMOGLOBIN

Question 4

Hb carrying 2,3-DPG

Answer 4

Deoxyhemoglobin

Question 5

Hb carrying O2

Answer 5

Oxyhemoglobin

Question 6

Hb carrying CO2

Answer 6

Carbaminohemoglobin

Question 7

Human polypeptide chain of Hemoglobin

Answer 7

α, β, γ, δ

Question 8

Human polypeptide chain of Hemoglobin:

Answer 8

HbF (α2, γ2)
HbA1 (α2, β2)
HbA2 (α2, δ2)

Question 9

In adult, ___ HbA1, ___ HbA2, ____ HbF

Answer 9

96%, 2%, 2%

Question 10

Much smaller than that of RBCs in number

Answer 10

LEUKOCYTES

Question 11

4,000-11,000/cumm

Answer 11

LEUKOCYTES

Question 12

when leukocytes leave the bloodstream by migrating between endothelial cells of the blood vessels

Answer 12

Diapedesis

Question 13

Both have azurophilic granules (lysosomes)

Answer 13

Granulocytes
Agranulocytes

Question 14

GRANULOCYTES:

Answer 14

NEUTROPHIL
EOSINOPHIL
BASOPHIL

Question 15

Formation of the granulocytes (NEB) under the influence of several cytokines, GCSF, GM-CSF, IL-1, IL-5, IL-6, TNF-alpha,

Answer 15

GRANULOCYTOPIESIS

Question 16

Descendant of CFU-GEMM to CFU-Eo (Eosinophil) and CFU-Ba (basophil) forming myeloblast as precursor cell

Answer 16

GRANULOCYTOPIESIS

Question 17

Neutrophil arise from CFU-GM to CFU-G forming myeloblast

Answer 17

GRANULOCYTOPIESIS

Question 18

Also known as Polymorphonuclear leukocytes

Answer 18

NEUTROPHIL

Question 19

The most abundant of all WBCs (60-70%)

Answer 19

NEUTROPHIL

Question 20

Multilobed nucleus

Answer 20

NEUTROPHIL

Question 21

In females, the nucleus presents a characteristic small appendages, the “drumstick” which contains the inactive x chromosome

Answer 21

NEUTROPHIL

Question 22

One of the first cells to appear during acute bacterial infection

Answer 22

NEUTROPHIL

Question 23

Phagocytose and destroy bacteria using the contents of their granules

Answer 23

NEUTROPHIL

Question 24

contain various enzymes and pharmacological agents in performing antimicrobial function

Answer 24

Specific granules

Question 25

are lysosomes containing acid hydrolases, MPO, BPI protein, antibacterial agent lysozyme, etc

Answer 25

Azurophilic granules

Question 26

gelatinase and cathepsins inserted into plasmalemma

Answer 26

Tertiary granules

Question 27

NEUTROPHILIC GRANULES:

Answer 27

Specific granules Azurophilic granules Tertiary granules

Question 28

Constitutes less than 4%of the total WBCs

Answer 28

EOSINOPHILS

Question 29

Sausage-shaped, bilobed nucleus

Answer 29

EOSINOPHILS

Question 30

Helps to eliminate antigen-antibody complexes and destroy parasitic worms

Answer 30

EOSINOPHILS

Question 31

EOSINOPHILS GRANULES: contains crystal-like center called internum, and surrounded by externum

Answer 31

Specific

Question 32

EOSINOPHILS GRANULES: Internum: major basic protein, eosinophilic cationic protein, eosinophil-derived neurotoin

Answer 32

Specific

Question 33

EOSINOPHILS GRANULES: lysosomes

Answer 33

Azurophilic granules

Question 34

The same function with mast cells but different origin (initiators of inflammatory process)

Answer 34

BASOPHIL

Question 35

Constitute less than 1% of the WBC population

Answer 35

BASOPHIL

Question 36

S-shaped nucleus but is commonly masked by the large specific granules

Answer 36

BASOPHIL

Question 37

BASOPHILS GRANULES: stain dark blue to black pressed against the periphery (roughened perimeter)

Answer 37

Specific granules

Question 38

BASOPHILS GRANULES: lysosomes

Answer 38

Azurophilic granules

Question 39

AGRANULOCYTES:

Answer 39

MONOCYTES LYMPHOCYTES

Question 40

Share bipotential cell with neutrophil CFU-GM

Answer 40

MONOCYTOPOIESIS

Question 41

CFU-M arises after the mitosis of CFU-GM forming monoblast

Answer 41

MONOCYTOPOIESIS

Question 42

The largest of the circulating blood cells, enter the connective tissue spaces, where they are known as macrophages

Answer 42

MONOCYTES

Question 43

Constitute 3-8% of the WBC population

Answer 43

MONOCYTES

Question 44

Large, eccentric, kidney-shaped nucleus

Answer 44

MONOCYTES

Question 45

Cytoplasm is bluish with numerous azurophilic granules (lysosomes)

Answer 45

MONOCYTES

Question 46

FUNCTION: inflammatory and immune response

Answer 46

MONOCYTES

Question 47

LYMPHOPOIESIS:

Answer 47

T LYMPHOCYTE B LYMPHOCYTE

Question 48

stem cell which give rise to immunocompetent B lymphocytesepressing special surface markers including antibodies

Answer 48

CFU-LyB

Question 49

cells undergo mitosis forming immunocompetent T cells

Answer 49

CFU-LyT

Question 50

Occurs in the bone marrow

Answer 50

CFU-LyB

Question 51

Occurs in the cortex of the thymus (maturation)

Answer 51

CFU-LyT

Question 52

Lymphoid Organs:

Answer 52

Spleen Lymph nodes