Blood and Hemopoiesis Part II Flashcards
Large protein composed of four polypeptide chains, each is bound to heme group (iron-containing)
HEMOGLOBIN
_____ moiety is responsible for releasing CO2
Globin
R state and T state
HEMOGLOBIN
Hb carrying 2,3-DPG
Deoxyhemoglobin
Hb carrying O2
Oxyhemoglobin
Hb carrying CO2
Carbaminohemoglobin
Human polypeptide chain of Hemoglobin
α, β, γ, δ
Human polypeptide chain of Hemoglobin:
HbF (α2, γ2)
HbA1 (α2, β2)
HbA2 (α2, δ2)
In adult, ___ HbA1, ___ HbA2, ____ HbF
96%, 2%, 2%
Much smaller than that of RBCs in number
LEUKOCYTES
4,000-11,000/cumm
LEUKOCYTES
when leukocytes leave the bloodstream by migrating between endothelial cells of the blood vessels
Diapedesis
Both have azurophilic granules (lysosomes)
Granulocytes
Agranulocytes
GRANULOCYTES:
NEUTROPHIL
EOSINOPHIL
BASOPHIL
Formation of the granulocytes (NEB) under the influence of several cytokines, GCSF, GM-CSF, IL-1, IL-5, IL-6, TNF-alpha,
GRANULOCYTOPIESIS
Descendant of CFU-GEMM to CFU-Eo (Eosinophil) and CFU-Ba (basophil) forming myeloblast as precursor cell
GRANULOCYTOPIESIS
Neutrophil arise from CFU-GM to CFU-G forming myeloblast
GRANULOCYTOPIESIS
Also known as Polymorphonuclear leukocytes
NEUTROPHIL
The most abundant of all WBCs (60-70%)
NEUTROPHIL
Multilobed nucleus
NEUTROPHIL