BIO Ch. 2 Reproduction Flashcards
What are the stages of interphase?
G0, G1, S,and G2
What happens in G0?
sells are simply living and serving their function without any preparation for division
What happens in G1?
cells create organelles or energy and protein productions while increasing their size. certain criteria must be met before the cell can proceed to the S stage
What happens in S?
cells replicate their genetic material so that each daughter cell will have identical copies and form sister chromatids
What happens in G2?
the cells check to ensure that there are enough organelles and cytoplasm to divide b/w 2 daughter cells and check to make sure DNA replication can proceed correctly
What happens in M1?
Mitosis and cytokinesis
What are the 4 phases of mitosis?
prophase - chromosomes condense, and spindle fibers form
metaphase -chromosomes align
anaphase - sister chromatids separate
telophase - new nuclear membrane forms
What is the purpose of the G1/S phase?
the cell determines if the DNA is in good enough condition for synthesis. if not, the cell goes into effect until it is repaired via P53
What is the purpose of the G2/M phase?
The cell is mainly concerned with ensuring that the cell has achieved adequate size and that organelles have been properly replicated to support 2 daughter cells via P53.
What is the role of cyclins and cyclic-dependent kinases (CDK)
cyclins bind to the CDKs, activating the CDK-cyclin complex. this complex can then phosphorylate transcription factions which promote the transcription of genes required for the next stage of the cell cycle
What happens when TP53 is mutated?
the cell cycle is not stopped to repair damaged DNA, and as a result, mutation accumulates. Cancer cells can undergo rapid cell division, creating tumors
What is mitosis?
the process by which 2 identical daughter cells are created from a single cell. this occurs in somatic cells
What happens in prophase?
- the chromatin condenses into chromosomes
- centriole pairs separate and move towards opposite poles of the cell
- the centrioles begin to form spindle fibers which are made up of microtubules
- the nuclear membrane dissolves, allowing the spindle fibers to contact the chromosomes
- the nucleoli disappears
- kinetochores appear at the centromere serving as an attachment point for kinetochore fibers on the spindle apparatus
What happens in Metaphase?
the centriole pairs are now at the opposite ends of the cell, and the kinetochore fibers interact with the spindle apparatus to align the chromosomes at the metaphase/equatorial plate
What happens in Anaphase?
the centromeres split so that each chromatid has its centrosomes, allowing the sister chromatids to separate, and the kinetochore fibers shorten