5.3.1 Myasthenia Gravis

Question 1

What is the clinical manifestation of Myasthenia Gravis?

Answer 1

Fluctuating weakness

Early involvement of cranial nerves: ptosis, double vision, Dysphagia, generalized weakness

Question 2

What are the important diagnostic tests for Myasthenia Gravis?

Answer 2

AchR antibodies - great specificity

Single-Fiber EMG - great sensitivity

Edrophonium Test

Repetitive Stimulation

Question 3

What are the treatments for Myasthenia Gravis?

Answer 3

Question 4

What is the pathophysiology of Myasthenia Gravis?

Answer 4

Competitive inhibition of the AchR

Inflammatory changes at the neuromuscular junction

Question 5

What is the natural history of Myasthenia gravis?

Answer 5

Question 6

What are the key points of repetitive stimulation in MG?

Answer 6

Question 7

What is the definition of myasthenia gravis?

Answer 7

Autoimmune disease of the neuromuscular junction caused by antibodies directed to the acetylcholine receptor or related proteins