Yersinia Flashcards
Gram stain
Gram negative
Morphology
Rod shaped, bipolar stain look like safety pin
Oxygen requirements
Facultatively anaerobic
Do the ferment lactos
no
Y. pestis disease
Plague
Y. Pseudotuberculosis
Enterocolitis and mesenteric lymphadenitis in birds, rodents, and sometimes domestic animals. Generalized nodular abscesses
Y. enterocolitica disease
Enterocolitis and mesenteric lymphadenitis in humans and domestic animals. Foodbourne pathogen
Habitat of enterocolitica and pseudotuberculosis
GI tract and lymph nodes especially pigs (enterocolitica)
Lymph nodes and lymphoid tissue trophism
-Y. pestis: site of entry
-Y. pseudotuberculosis and entercolitica: Peyers patches and mesenteric lymph nodes
Habitat of pestis
Rodents, rabbits, squirrels, prairie dogs and others in sporadic pockets in US and europe and asia
Modes of infection of plague
-Flea bites
-Inhale aerosols
-Contact with infected person or dead animals
-Cat bites
-Ingestion (in cats)
Sylvatic plague
Plague in rodents where they serve as maintenance hosts and transmitted by fleas. Source of infection to animals and humans
Virulence factors of pestis
-Fraction 1 protein capsular
-Capsule
-LPS
-Yersiniobactin: siderophore
-Toxins
Toxins in pestis
-Yops
-LerV
-Murine toxin
-Pesticin
-Coagulase
Plague in domestic animals
Cats highly susceptible. Other animals may get infected by flea bites or eating forages by contaminated rodents
-Dogs get infected but no clinical signs