Brucella Flashcards

1
Q

General features

A

Gram negative
Short rods (coccobacilli)
Aerobic
Some carboxyphilic
Facultatively intracellular pathogen
Oxidase positive

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2
Q

Classical brucella

A

abortus
suis
melitensis
-Potential bioweapons
-Highly infectious
-Easily aerosolized
-difficult to detect

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3
Q

Transmission

A

Oral (ingestion or milk from infected cows to calves) or venereal

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4
Q

Brucellosis

A

Infectious of the repro organs
-Cause abortions
-Zoonotic disease

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5
Q

Erythritol

A

Growth factor in placenta and testicles (not in humans) some species of brucella require

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6
Q

Geographic distribution

A

Worldwide
Considered eradicated in US

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7
Q

Virulence factors

A

-Endotoxin
-Ability to survive in macrophages

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8
Q

Diseases

A

-Contagious abortions
-Infertility, mastitis
-Bulls: orchitis and epididymitis. Affects joints

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9
Q

Lesions

A

Granulomatous and suppurative

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10
Q

Diagnosis

A

-Difficult in bulls and nonpregnant (asymptomatic)
-Suspect if see multiple abortions
-Examine cultures
-PCR assay for species confirmation
-Serology

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11
Q

Treatment

A

Can not treat in food animals -Slaughter
Treat dogs with aminoglycosides or tetracyclines

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12
Q

Vaccines

A

-Live attenuated strain only for females causes sterility in males (not used)
-RB51 strain-cell mediated immunity for all adults

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13
Q

National Brucellosis Eradication Program

A
  1. Detect infected animals
  2. Reactors branded and slaughtered
  3. Herds with suspects are quarantined
  4. Vaccination of calves
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14
Q

Class free

A

No positive herd for one year or if there was one they kill the herd and thoroughly test all adjacent herds

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15
Q

Brucella suis

A

Can infect any animal

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16
Q

Transmission of brucella suis

A

-Ingestion
-Nursery pigs from infected sows
-Venereal

17
Q

B. suis signs

A

-Abortion
-Sterility
-Still births
-Spondylitis
-Abscesses

18
Q

Control of B. suis

A

Eradicated

19
Q

Brucella ovis

A

Least pathogenic

20
Q

Transmission of B. ovis

A

Venereal

21
Q

Signs of B. ovis

A

-Epididymitis in rams
-Abortion and infertility

22
Q

Brucella canis

A

Only infects dogs

23
Q

Transmission of B. canis

A

Oral and venereal
highly contagious

24
Q

Pathogenesis of B. canis

A

Secreted in vaginal secretion, urine, or semen-> gets phagocytized-> ln->blood->repro tract

25
Q

B. canis signs

A

Abortion and infertility
-Persistent vaginal discharge with canis
-Epididymitis and prostatitis
-Testicular atrophy and sterility

26
Q

Diagnosis of B. canis

A
  1. Culture or PCR
  2. Necropsy
  3. Serology: agglutination test
27
Q

Treatment of B. canis

A

-Aminoglycosides
-Tetracyclines
-Doxy with gentamicin
-Long term

28
Q

Prevention

A

No vaccine
Kill infected animals

29
Q

Brucella in horses

A

-Arthritis
-Atlantal bursitis (poll evil)
-Supraspinatus bursitis (fistulous withers)

30
Q

Brucella in goats

A

Melitensis most common
-Abortion
-Orchitis

31
Q

Brucella in humans

A

Melitensis most serious infection (Malta fever)
-Changed from occupational to foodborne disease

32
Q

Signs of brucella in humans

A

Chronic fatigue syndrome
-Long incubation period
-Undulant fever