Lawsonia Helicobacter Flashcards
General features of Lawosnia
Gram negative
Helical shape
-Obligate intracellular pathogen
Swine proliferative enteritis
-Proliferation of enterocytes in ileum, cecum and colon
-Caused by L. intracellularis through ingestion
-See thickening of the mucosa
Virulence factors of L. intracellularis
-LPS
-Surface antigen A
-Adhesion
Four forms of Swine proliferative enteritis
- Chronic proliferative enteropathy: thick mucosa from hyperplasia
- Necrotic enteritis
- Regional ileitis: chronic with thick muscle
- Acute hemorrhagic enteropathy: hemorrhage into lumen (melena)
Clinical signs of swine proliferative enteritis
Acute: See in 4-12mo, diarrhea with brown or black unclotted blood, weakness, death
Subacute or chronic: in grower pigs, sporadic diarrhea, reduced weight gain and growth rate
Treatment of Swine proliferative enteritis
Whole herd feed additives
-Tiamulin
-Chlortetracycline
-Tylosin
-Vaccine avirulent live
Equine proliferative enteropathy
Effects 2-8mo from August to January
-Fever, diarrhea, colic, ventral edema, hypoproteinemia
-Lesions: thickened mucosa of the ileum near ileo-cecal junction
Treatment of equine proliferative enteropathy
-Macrolides and rifampin
-Chloramphenicol
-Oxytetracycline or Doxycycline for 3 weeks
-Swine vaccine used
Helicobacter general features
Gram negative
Helicobacter
Two groups: Gastric and enterohepatic
3 flagella
Chronic gastritis and gastric and duodenal ulcers
Helicobacter pylori
-Chronic disease and can cause gastric lymphoma or adenocarcinoma
-Break through mucous to gastric epithelial cells and are able to form ammonia and cause ulcers
Virulence factors of Helicobacter pylori
-Urease
-Motility
-Mucinase
-Adhesion: BapA and HpaA
-Vacuolating cytotoxin
-Neutrophil activating protein
