Xanthine Oxidase Inhibitors

Question 1

Name 2 Xanthine Oxidase Inhibitors.

Answer 1

1. Allopurinol

2. Febuxostat

Question 2

How should allopurinol be initiated?

Answer 2

Allopurinol should be started gradually to avoid hypersensitivity reactions and to avoid rapid changes in serum urate which may precipitate gout.

Question 3

What are the two indications of allopurinol as per Medication Profiler?

Answer 3

1. To prevent gout

2. To prevent tumour lysis syndrome

Question 4

What does the “other important information” section on MedProfiler say about allopurinol?

Answer 4

Take with food and plenty of fluid to avoid stomach irritation.
Report skin rashes to your doctor immediately.
May decrease alertness in the first few days of therapy.