Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

INTERNSHIP > Immunomodulators and Antineoplastics > Flashcards

Immunomodulators and Antineoplastics Flashcards

1
Q

Name 4 classes of alkylating agents

A
  1. Nitrogen mustards
  2. Nitrosoureas
  3. Triazenes
  4. Others
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Name 5 nitrogen mustard alkylating agents

A
  1. bendamustine
  2. Chlorambucil
  3. CYCLOPHOSPHamide
  4. iFOSFamide
  5. melphalan
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name 3 nitrosoureas

A
  1. carmustine
  2. fotemustine
  3. lomustine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Name 2 miscellaneous alkylating agents

A
  1. busulfan

2. procarbazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name 5 anthracyclines

A
  1. DAUNOrubicin
  2. DOXOrubicin
  3. Epirubicin
  4. iDArubicin
  5. Mitozantron
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name 4 classes of antimetabolites

A
  1. Folic acid antagonists
  2. Purine antagonists
  3. Pyrimidine antagonists
  4. Others
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name 4 classes of folic acid antagonist antimetabolites

A
  1. Methotrexate
  2. Pemetrexed
  3. Pralatrexate
  4. Raltitrexed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name 5 purine antagonist antimetabolites

A
  1. cladribine
  2. clofarabine
  3. fludarabine
  4. mercaptOPURine
  5. tioguanine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Name 6 pyrimidine antagonist antimetabolites

A
  1. azacitidine
  2. capecitabine
  3. cytarabine
  4. fluorouracil
  5. gemcitabine
  6. trifluridine with tipiracil
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What class of drug is hydroxycarbamide?

A

Antimetabolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Name 3 platinum compounds

A
  1. cARBOplatin
  2. ciSplatin
  3. oxaliplatin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Name 2 proteasome inhibitors

A
  1. bortezomib

2. carfilzomib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name 3 taxanes

A
  1. cabazitaxel
  2. DOCEtaxel
  3. PACLitaxel
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name 2 Topoisomerase I inhibitors

A
  1. Irinotecan

2. Topotecan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Name 3 vinca alkaloids

A
  1. vinBLASTine
  2. vinCRISTine
  3. vinORELBine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What class of drug is bleomycin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What class of drug is brentuximab vedotin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What class of drug is daCTINomycin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What class of drug is eribulin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What class of drug is etoposide?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What class of drug is gemtuzumab ozogamicin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What class of drug is inotuzumab ozogamicin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What class of drug is mitomycin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What class of drug is niraparib?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What class of drug is olaparib?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What class of drug is romidepsin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What class of drug is sacituzumab govitecan?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What class of drug is trabectedin?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What class of drug is trastuzumab deruxtecan?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What class of drug is trastuzumab emtansine?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What class of drug is venetoclax?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What class of drug is vorinostat?

A

Cytotoxic antineoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What class of drug is alemtuzumab?

A

Kinase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What class of drug atezolizumab?

A

Kinase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What class of drug avelumab?

A

Kinase inhibitor

36
Q

What class of drug bevacizumab?

A

Kinase inhibitor

37
Q

What class of drug blinatumomab?

A

Kinase inhibitor

38
Q

What class of drug cetuximab?

A

Kinase inhibitor

39
Q

What class of drug daratumumab?

A

Kinase inhibitor

40
Q

What class of drug durvalumab?

A

Kinase inhibitor

41
Q

What class of drug elotuzumab?

A

Kinase inhibitor

42
Q

What class of drug ipilimumab?

A

Kinase inhibitor

43
Q

What class of drug nivolumab?

A

Kinase inhibitor

44
Q

What class of drug obinutuzumab?

A

Kinase inhibitor

45
Q

What class of drug panitumumab?

A

Kinase inhibitor

46
Q

What class of drug pembrolizumab?

A

Kinase inhibitor

47
Q

What class of drug pertuzumab?

A

Kinase inhibitor

48
Q

What class of drug ramucirumab?

A

Kinase inhibitor

49
Q

What class of drug rituximab?

A

Kinase inhibitor

50
Q

What class of drug siltuximab?

A

Kinase inhibitor

51
Q

What class of drug trastuzumab?

A

Kinase inhibitor

52
Q

Name 3 thalidomide analogues?

A
  1. Lenalidomide
  2. Pomalidomide
  3. Thalidomide
53
Q

What class of drug is anagrelide?

A

Non-cytotoxic antineoplastic

54
Q

What class of drug is arsenic trioxide?

A

Non-cytotoxic antineoplastic

55
Q

What class of drug is BCG?

A

Non-cytotoxic antineoplastic

56
Q

What class of drug is everolimus?

A

Non-cytotoxic antineoplastic

57
Q

What class of drug is pegaspargase?

A

Non-cytotoxic antineoplastic

58
Q

What class of drug is sonidegib?

A

Non-cytotoxic antineoplastic

59
Q

What class of drug is tretinoin?

A

Non-cytotoxic antineoplastic

60
Q

What class of drug is vismodegib?

A

Non-cytotoxic antineoplastic

61
Q

What are the 2 classes of anti-androgens?

A
  1. Nonsteroidal anti-androgens

2. Steroidal anti-androgens

62
Q

Name 5 nonsteroidal anti-androgens

A
  1. Apalutamide
  2. Bicalutamide
  3. Darolutamide
  4. Enzalutamide
  5. Flutamide
63
Q

Name 1 steroidal anti-androgen

A

Cyproterone

64
Q

Name 3 aromatase inhibitors

A
  1. Anastrozole
  2. Exemestane
  3. Letrozole
65
Q

Name 3 gonadotrophin-releasing hormone agonists

A
  1. Goserelin
  2. Leuprorelin
  3. Triptorelin
66
Q

Name 2 selective estrogen receptor modulators

A
  1. Tamoxifen

2. Toremifene

67
Q

What class of drug is abiraterone?

A

Hormonal antineoplastic

68
Q

What class of drug is degarelix?

A

Hormonal antineoplastic

69
Q

What class of drug is fulvestrant?

A

Hormonal antineoplastic

70
Q

Name 2 G‑CSFs

A
  1. Filgrastim

2. Lenograstim

71
Q

What class of drug is amifostine?

A

Drugs used with antineoplastics

72
Q

What class of drug is calcium folinate?

A

Drugs used with antineoplastics

73
Q

What class of drug is mesna?

A

Drugs used with antineoplastics

74
Q

What class of drug is palifermin?

A

Drugs used with antineoplastics

75
Q

What class of drug is plerixafor?

A

Drugs used with antineoplastics

76
Q

What class of drug is rasburicase?

A

Drugs used with antineoplastics

77
Q

Name 2 calcineurin inhibitors

A
  1. ciclosPORIN

2. TACrolimus

78
Q

Name 17 corticosteroids

A
  1. Beclometasone
  2. Betamethasone
  3. Budesonide
  4. Ciclesonide
  5. Clobetasol
  6. Clobetasone
  7. Cortisone
  8. Desonide
  9. Dexamethasone
  10. Fludrocortisone
  11. Fluorometholone
  12. Fluticasone
  13. Hydrocortisone
  14. Methylprednisolone
  15. Mometasone
  16. Prednisolone/prednisone
  17. Triamcinolone
79
Q

Name 2 types of immunosuppressant antibodies

A
  1. Antithymocyte globulins

2. Basiliximab

80
Q

Name 2 mTOR inhibitors

A
  1. Everolimus

2. Sirolimus

81
Q

Name 2 immunosuppressants

A
  1. azATHIOPRINE

2. mycophenolate

82
Q

Name 3 interferons

A
  1. Interferon beta
  2. Interferon gamma
  3. Peginterferon alfa-2a
83
Q

What is a practical limitation of azATHIOPRINE in IBD?

A

It takes months to work

84
Q

How is azATHIOPRINE normally initiated in hospital for IBD patients?

A

Normally, patients will start 40 mg prednisolone when they start azATHIOPRINE and taper the prednisolone at 5 mg/week, so by the time the prednisolone course is completed, azATHIOPRINE should have taken effect.

85
Q

What is the risk of interaction between xanthine oxidase inhibitors and azATHIOPRINE?

A

Xanthine oxidase inhibitors increase the risk of bone marrow suppression with azATHIOPRINE.

86
Q

Describe the deliberate use of interaction between xanthine oxidase inhibitors and azATHIOPRINE.

A

Very rarely this is done deliberately to boost responses in patients with high TPMT activity. This is extremely rare and as such you should query it with the team every single time you see it.

INTERNSHIP (197 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions