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Immunomodulators and Antineoplastics Flashcards

1
Q

Name 4 classes of alkylating agents

A
  1. Nitrogen mustards
  2. Nitrosoureas
  3. Triazenes
  4. Others
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2
Q

Name 5 nitrogen mustard alkylating agents

A
  1. bendamustine
  2. Chlorambucil
  3. CYCLOPHOSPHamide
  4. iFOSFamide
  5. melphalan
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3
Q

Name 3 nitrosoureas

A
  1. carmustine
  2. fotemustine
  3. lomustine
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4
Q

Name 2 miscellaneous alkylating agents

A
  1. busulfan

2. procarbazine

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5
Q

Name 5 anthracyclines

A
  1. DAUNOrubicin
  2. DOXOrubicin
  3. Epirubicin
  4. iDArubicin
  5. Mitozantron
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6
Q

Name 4 classes of antimetabolites

A
  1. Folic acid antagonists
  2. Purine antagonists
  3. Pyrimidine antagonists
  4. Others
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7
Q

Name 4 classes of folic acid antagonist antimetabolites

A
  1. Methotrexate
  2. Pemetrexed
  3. Pralatrexate
  4. Raltitrexed
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8
Q

Name 5 purine antagonist antimetabolites

A
  1. cladribine
  2. clofarabine
  3. fludarabine
  4. mercaptOPURine
  5. tioguanine
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9
Q

Name 6 pyrimidine antagonist antimetabolites

A
  1. azacitidine
  2. capecitabine
  3. cytarabine
  4. fluorouracil
  5. gemcitabine
  6. trifluridine with tipiracil
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10
Q

What class of drug is hydroxycarbamide?

A

Antimetabolite

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11
Q

Name 3 platinum compounds

A
  1. cARBOplatin
  2. ciSplatin
  3. oxaliplatin
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12
Q

Name 2 proteasome inhibitors

A
  1. bortezomib

2. carfilzomib

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13
Q

Name 3 taxanes

A
  1. cabazitaxel
  2. DOCEtaxel
  3. PACLitaxel
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14
Q

Name 2 Topoisomerase I inhibitors

A
  1. Irinotecan

2. Topotecan

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15
Q

Name 3 vinca alkaloids

A
  1. vinBLASTine
  2. vinCRISTine
  3. vinORELBine
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16
Q

What class of drug is bleomycin?

A

Cytotoxic antineoplastic

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17
Q

What class of drug is brentuximab vedotin?

A

Cytotoxic antineoplastic

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18
Q

What class of drug is daCTINomycin?

A

Cytotoxic antineoplastic

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19
Q

What class of drug is eribulin?

A

Cytotoxic antineoplastic

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20
Q

What class of drug is etoposide?

A

Cytotoxic antineoplastic

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21
Q

What class of drug is gemtuzumab ozogamicin?

A

Cytotoxic antineoplastic

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22
Q

What class of drug is inotuzumab ozogamicin?

A

Cytotoxic antineoplastic

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23
Q

What class of drug is mitomycin?

A

Cytotoxic antineoplastic

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24
Q

What class of drug is niraparib?

A

Cytotoxic antineoplastic

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25
What class of drug is olaparib?
Cytotoxic antineoplastic
26
What class of drug is romidepsin?
Cytotoxic antineoplastic
27
What class of drug is sacituzumab govitecan?
Cytotoxic antineoplastic
28
What class of drug is trabectedin?
Cytotoxic antineoplastic
29
What class of drug is trastuzumab deruxtecan?
Cytotoxic antineoplastic
30
What class of drug is trastuzumab emtansine?
Cytotoxic antineoplastic
31
What class of drug is venetoclax?
Cytotoxic antineoplastic
32
What class of drug is vorinostat?
Cytotoxic antineoplastic
33
What class of drug is alemtuzumab?
Kinase inhibitor
34
What class of drug atezolizumab?
Kinase inhibitor
35
What class of drug avelumab?
Kinase inhibitor
36
What class of drug bevacizumab?
Kinase inhibitor
37
What class of drug blinatumomab?
Kinase inhibitor
38
What class of drug cetuximab?
Kinase inhibitor
39
What class of drug daratumumab?
Kinase inhibitor
40
What class of drug durvalumab?
Kinase inhibitor
41
What class of drug elotuzumab?
Kinase inhibitor
42
What class of drug ipilimumab?
Kinase inhibitor
43
What class of drug nivolumab?
Kinase inhibitor
44
What class of drug obinutuzumab?
Kinase inhibitor
45
What class of drug panitumumab?
Kinase inhibitor
46
What class of drug pembrolizumab?
Kinase inhibitor
47
What class of drug pertuzumab?
Kinase inhibitor
48
What class of drug ramucirumab?
Kinase inhibitor
49
What class of drug rituximab?
Kinase inhibitor
50
What class of drug siltuximab?
Kinase inhibitor
51
What class of drug trastuzumab?
Kinase inhibitor
52
Name 3 thalidomide analogues?
1. Lenalidomide 2. Pomalidomide 3. Thalidomide
53
What class of drug is anagrelide?
Non-cytotoxic antineoplastic
54
What class of drug is arsenic trioxide?
Non-cytotoxic antineoplastic
55
What class of drug is BCG?
Non-cytotoxic antineoplastic
56
What class of drug is everolimus?
Non-cytotoxic antineoplastic
57
What class of drug is pegaspargase?
Non-cytotoxic antineoplastic
58
What class of drug is sonidegib?
Non-cytotoxic antineoplastic
59
What class of drug is tretinoin?
Non-cytotoxic antineoplastic
60
What class of drug is vismodegib?
Non-cytotoxic antineoplastic
61
What are the 2 classes of anti-androgens?
1. Nonsteroidal anti-androgens | 2. Steroidal anti-androgens
62
Name 5 nonsteroidal anti-androgens
1. Apalutamide 2. Bicalutamide 3. Darolutamide 4. Enzalutamide 5. Flutamide
63
Name 1 steroidal anti-androgen
Cyproterone
64
Name 3 aromatase inhibitors
1. Anastrozole 2. Exemestane 3. Letrozole
65
Name 3 gonadotrophin-releasing hormone agonists
1. Goserelin 2. Leuprorelin 3. Triptorelin
66
Name 2 selective estrogen receptor modulators
1. Tamoxifen | 2. Toremifene
67
What class of drug is abiraterone?
Hormonal antineoplastic
68
What class of drug is degarelix?
Hormonal antineoplastic
69
What class of drug is fulvestrant?
Hormonal antineoplastic
70
Name 2 G‑CSFs
1. Filgrastim | 2. Lenograstim
71
What class of drug is amifostine?
Drugs used with antineoplastics
72
What class of drug is calcium folinate?
Drugs used with antineoplastics
73
What class of drug is mesna?
Drugs used with antineoplastics
74
What class of drug is palifermin?
Drugs used with antineoplastics
75
What class of drug is plerixafor?
Drugs used with antineoplastics
76
What class of drug is rasburicase?
Drugs used with antineoplastics
77
Name 2 calcineurin inhibitors
1. ciclosPORIN | 2. TACrolimus
78
Name 17 corticosteroids
1. Beclometasone 2. Betamethasone 3. Budesonide 4. Ciclesonide 5. Clobetasol 6. Clobetasone 7. Cortisone 8. Desonide 9. Dexamethasone 10. Fludrocortisone 11. Fluorometholone 12. Fluticasone 13. Hydrocortisone 14. Methylprednisolone 15. Mometasone 16. Prednisolone/prednisone 17. Triamcinolone
79
Name 2 types of immunosuppressant antibodies
1. Antithymocyte globulins | 2. Basiliximab
80
Name 2 mTOR inhibitors
1. Everolimus | 2. Sirolimus
81
Name 2 immunosuppressants
1. azATHIOPRINE | 2. mycophenolate
82
Name 3 interferons
1. Interferon beta 2. Interferon gamma 3. Peginterferon alfa-2a
83
What is a practical limitation of azATHIOPRINE in IBD?
It takes months to work
84
How is azATHIOPRINE normally initiated in hospital for IBD patients?
Normally, patients will start 40 mg prednisolone when they start azATHIOPRINE and taper the prednisolone at 5 mg/week, so by the time the prednisolone course is completed, azATHIOPRINE should have taken effect.
85
What is the risk of interaction between xanthine oxidase inhibitors and azATHIOPRINE?
Xanthine oxidase inhibitors increase the risk of bone marrow suppression with azATHIOPRINE.
86
Describe the deliberate use of interaction between xanthine oxidase inhibitors and azATHIOPRINE.
Very rarely this is done deliberately to boost responses in patients with high TPMT activity. This is extremely rare and as such you should query it with the team every single time you see it.

INTERNSHIP (197 decks)

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