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INTERNSHIP > Immunomodulators and Antineoplastics > Flashcards

Immunomodulators and Antineoplastics Flashcards

1
Q

Name 4 classes of alkylating agents

A
  1. Nitrogen mustards
  2. Nitrosoureas
  3. Triazenes
  4. Others
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2
Q

Name 5 nitrogen mustard alkylating agents

A
  1. bendamustine
  2. Chlorambucil
  3. CYCLOPHOSPHamide
  4. iFOSFamide
  5. melphalan
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3
Q

Name 3 nitrosoureas

A
  1. carmustine
  2. fotemustine
  3. lomustine
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4
Q

Name 2 miscellaneous alkylating agents

A
  1. busulfan

2. procarbazine

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5
Q

Name 5 anthracyclines

A
  1. DAUNOrubicin
  2. DOXOrubicin
  3. Epirubicin
  4. iDArubicin
  5. Mitozantron
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6
Q

Name 4 classes of antimetabolites

A
  1. Folic acid antagonists
  2. Purine antagonists
  3. Pyrimidine antagonists
  4. Others
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7
Q

Name 4 classes of folic acid antagonist antimetabolites

A
  1. Methotrexate
  2. Pemetrexed
  3. Pralatrexate
  4. Raltitrexed
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8
Q

Name 5 purine antagonist antimetabolites

A
  1. cladribine
  2. clofarabine
  3. fludarabine
  4. mercaptOPURine
  5. tioguanine
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9
Q

Name 6 pyrimidine antagonist antimetabolites

A
  1. azacitidine
  2. capecitabine
  3. cytarabine
  4. fluorouracil
  5. gemcitabine
  6. trifluridine with tipiracil
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10
Q

What class of drug is hydroxycarbamide?

A

Antimetabolite

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11
Q

Name 3 platinum compounds

A
  1. cARBOplatin
  2. ciSplatin
  3. oxaliplatin
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12
Q

Name 2 proteasome inhibitors

A
  1. bortezomib

2. carfilzomib

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13
Q

Name 3 taxanes

A
  1. cabazitaxel
  2. DOCEtaxel
  3. PACLitaxel
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14
Q

Name 2 Topoisomerase I inhibitors

A
  1. Irinotecan

2. Topotecan

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15
Q

Name 3 vinca alkaloids

A
  1. vinBLASTine
  2. vinCRISTine
  3. vinORELBine
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16
Q

What class of drug is bleomycin?

A

Cytotoxic antineoplastic

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17
Q

What class of drug is brentuximab vedotin?

A

Cytotoxic antineoplastic

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18
Q

What class of drug is daCTINomycin?

A

Cytotoxic antineoplastic

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19
Q

What class of drug is eribulin?

A

Cytotoxic antineoplastic

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20
Q

What class of drug is etoposide?

A

Cytotoxic antineoplastic

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21
Q

What class of drug is gemtuzumab ozogamicin?

A

Cytotoxic antineoplastic

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22
Q

What class of drug is inotuzumab ozogamicin?

A

Cytotoxic antineoplastic

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23
Q

What class of drug is mitomycin?

A

Cytotoxic antineoplastic

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24
Q

What class of drug is niraparib?

A

Cytotoxic antineoplastic

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25
Q

What class of drug is olaparib?

A

Cytotoxic antineoplastic

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26
Q

What class of drug is romidepsin?

A

Cytotoxic antineoplastic

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27
Q

What class of drug is sacituzumab govitecan?

A

Cytotoxic antineoplastic

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28
Q

What class of drug is trabectedin?

A

Cytotoxic antineoplastic

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29
Q

What class of drug is trastuzumab deruxtecan?

A

Cytotoxic antineoplastic

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30
Q

What class of drug is trastuzumab emtansine?

A

Cytotoxic antineoplastic

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31
Q

What class of drug is venetoclax?

A

Cytotoxic antineoplastic

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32
Q

What class of drug is vorinostat?

A

Cytotoxic antineoplastic

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33
Q

What class of drug is alemtuzumab?

A

Kinase inhibitor

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34
Q

What class of drug atezolizumab?

A

Kinase inhibitor

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35
Q

What class of drug avelumab?

A

Kinase inhibitor

36
Q

What class of drug bevacizumab?

A

Kinase inhibitor

37
Q

What class of drug blinatumomab?

A

Kinase inhibitor

38
Q

What class of drug cetuximab?

A

Kinase inhibitor

39
Q

What class of drug daratumumab?

A

Kinase inhibitor

40
Q

What class of drug durvalumab?

A

Kinase inhibitor

41
Q

What class of drug elotuzumab?

A

Kinase inhibitor

42
Q

What class of drug ipilimumab?

A

Kinase inhibitor

43
Q

What class of drug nivolumab?

A

Kinase inhibitor

44
Q

What class of drug obinutuzumab?

A

Kinase inhibitor

45
Q

What class of drug panitumumab?

A

Kinase inhibitor

46
Q

What class of drug pembrolizumab?

A

Kinase inhibitor

47
Q

What class of drug pertuzumab?

A

Kinase inhibitor

48
Q

What class of drug ramucirumab?

A

Kinase inhibitor

49
Q

What class of drug rituximab?

A

Kinase inhibitor

50
Q

What class of drug siltuximab?

A

Kinase inhibitor

51
Q

What class of drug trastuzumab?

A

Kinase inhibitor

52
Q

Name 3 thalidomide analogues?

A
  1. Lenalidomide
  2. Pomalidomide
  3. Thalidomide
53
Q

What class of drug is anagrelide?

A

Non-cytotoxic antineoplastic

54
Q

What class of drug is arsenic trioxide?

A

Non-cytotoxic antineoplastic

55
Q

What class of drug is BCG?

A

Non-cytotoxic antineoplastic

56
Q

What class of drug is everolimus?

A

Non-cytotoxic antineoplastic

57
Q

What class of drug is pegaspargase?

A

Non-cytotoxic antineoplastic

58
Q

What class of drug is sonidegib?

A

Non-cytotoxic antineoplastic

59
Q

What class of drug is tretinoin?

A

Non-cytotoxic antineoplastic

60
Q

What class of drug is vismodegib?

A

Non-cytotoxic antineoplastic

61
Q

What are the 2 classes of anti-androgens?

A
  1. Nonsteroidal anti-androgens

2. Steroidal anti-androgens

62
Q

Name 5 nonsteroidal anti-androgens

A
  1. Apalutamide
  2. Bicalutamide
  3. Darolutamide
  4. Enzalutamide
  5. Flutamide
63
Q

Name 1 steroidal anti-androgen

A

Cyproterone

64
Q

Name 3 aromatase inhibitors

A
  1. Anastrozole
  2. Exemestane
  3. Letrozole
65
Q

Name 3 gonadotrophin-releasing hormone agonists

A
  1. Goserelin
  2. Leuprorelin
  3. Triptorelin
66
Q

Name 2 selective estrogen receptor modulators

A
  1. Tamoxifen

2. Toremifene

67
Q

What class of drug is abiraterone?

A

Hormonal antineoplastic

68
Q

What class of drug is degarelix?

A

Hormonal antineoplastic

69
Q

What class of drug is fulvestrant?

A

Hormonal antineoplastic

70
Q

Name 2 G‑CSFs

A
  1. Filgrastim

2. Lenograstim

71
Q

What class of drug is amifostine?

A

Drugs used with antineoplastics

72
Q

What class of drug is calcium folinate?

A

Drugs used with antineoplastics

73
Q

What class of drug is mesna?

A

Drugs used with antineoplastics

74
Q

What class of drug is palifermin?

A

Drugs used with antineoplastics

75
Q

What class of drug is plerixafor?

A

Drugs used with antineoplastics

76
Q

What class of drug is rasburicase?

A

Drugs used with antineoplastics

77
Q

Name 2 calcineurin inhibitors

A
  1. ciclosPORIN

2. TACrolimus

78
Q

Name 17 corticosteroids

A
  1. Beclometasone
  2. Betamethasone
  3. Budesonide
  4. Ciclesonide
  5. Clobetasol
  6. Clobetasone
  7. Cortisone
  8. Desonide
  9. Dexamethasone
  10. Fludrocortisone
  11. Fluorometholone
  12. Fluticasone
  13. Hydrocortisone
  14. Methylprednisolone
  15. Mometasone
  16. Prednisolone/prednisone
  17. Triamcinolone
79
Q

Name 2 types of immunosuppressant antibodies

A
  1. Antithymocyte globulins

2. Basiliximab

80
Q

Name 2 mTOR inhibitors

A
  1. Everolimus

2. Sirolimus

81
Q

Name 2 immunosuppressants

A
  1. azATHIOPRINE

2. mycophenolate

82
Q

Name 3 interferons

A
  1. Interferon beta
  2. Interferon gamma
  3. Peginterferon alfa-2a
83
Q

What is a practical limitation of azATHIOPRINE in IBD?

A

It takes months to work

84
Q

How is azATHIOPRINE normally initiated in hospital for IBD patients?

A

Normally, patients will start 40 mg prednisolone when they start azATHIOPRINE and taper the prednisolone at 5 mg/week, so by the time the prednisolone course is completed, azATHIOPRINE should have taken effect.

85
Q

What is the risk of interaction between xanthine oxidase inhibitors and azATHIOPRINE?

A

Xanthine oxidase inhibitors increase the risk of bone marrow suppression with azATHIOPRINE.

86
Q

Describe the deliberate use of interaction between xanthine oxidase inhibitors and azATHIOPRINE.

A

Very rarely this is done deliberately to boost responses in patients with high TPMT activity. This is extremely rare and as such you should query it with the team every single time you see it.

INTERNSHIP (189 decks)

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