Memantine

Question 1

What is the maximum daily dose of memantine for an adult with a glomerular filtration rate (GFR) between 5 and 29 mL per minute?

Answer 1

10 mg

Question 2

Memantine should be avoided below what GFR?

Answer 2

5 mL/min.

Question 3

Describe the evidence for memantine in dementia with Lewy bodies

Answer 3

The evidence for memantine for dementia with Lewy bodies is unclear.

Question 4

If a patient is experiencing intolerable adverse effects at lowest possible dosage of memantine, what can be done?

Answer 4

Cease treatment

Question 5

If a patient’s cognition and function has not improved or stabilised after using the maximum tolerated dose of memantine for at least 6 months, what can be done?

Answer 5

Cease treatment

Question 6

If, after initial improvement, a patient’s cognition and/or function has significantly worsen while using the maximum tolerated dose of memantine for at least 6 months, what can be done?

Answer 6

Cease treatment