Dopamine Antagonists

Question 1

Name 5 dopamine antagonists

Answer 1

1. Domperidone
2. Droperidol (gastrointestinal)
3. Haloperidol
4. Metoclopramide
5. proCHLORPERazine

Question 2

What is the drug class of proCHLORPERazine?

Answer 2

Dopamine antagonist

Question 3

Can prochlorperazine be used as monotherapy to manage migraine?

Answer 3

Yes, prochlorperazine can be given either IV (abortive therapy) or oral (for nausea, although less likely to be used as monotherapy)

Question 4

What are 9 common adverse effects of proCHLORPERazine?

Answer 4

1. Constipation
2. Dry mouth
3. Drowsiness
4. Akathisia
5. Parkinsonism
6. Blurred vision
7. EPSE (especially in children)
8. Hypotension
9. Hyperprolactinaemia

Question 5

What is an important counselling point with proCHLORPERazine?

Answer 5

This medication may make you drowsy and may increase the effects of alcohol. Avoid driving or operating machinery until you know how you are affected.

Question 6

Describe the CNS effects of proCHLORPERazine

Answer 6

proCHLORPERazine potentiates CNS depression

Question 7

Describe the intended duration of use of proCHLORPERazine

Answer 7

proCHLORPERazine is intended for short-term use only. The risk of tardive dyskinesia increases with cumulative doses and increasing length of treatment.

Question 8

What is the active ingredient in Stemetil?

Answer 8

Prochlorperazine

Question 9

What is an example of a patient group metoclopramide should be avoided in?

Answer 9

Patients with Parkinson’s Disease.