Parenteral Compatibility/Stability

Question 1

What are 10 factors to consider relating to parenteral compatibility/stability?

Answer 1

1. CONCENTRATIONS – compatibility is often concentration dependent
2. DILUENT– medication must be compatible with diluent
3. LINES AND LUMENS – peripheral or central, number of lumens in central line
4. HOW WILL THE MEDICATIONS COME INTO CONTACT – Y-site, admixture, syringe
5. ADMINISTRATION RATES – indicates duration of contact
6. CONTAINER – PVC, polyethylene, polyurethane, polyolefin
7. OTHER PARENTERAL MEDICATIONS/ FLUIDS – provides alternative compatibility options
8. pH – medications unlikely to be compatible if there is a large difference in pH
9. SAFETY – will administration change the rate of the medication already running. Is this safe/appropriate?
10. ALTERNATIVE – route of administration (eg rectal)