Statins (HMG-CoA reductase inhibitors)

Question 1

Name 5 Statins (HMG-CoA reductase inhibitors).

Answer 1

1. Atorvastatin
2. Fluvastatin
3. Pravastatin
4. Rosuvastatin
5. Simvastatin

Question 2

What is the risk of atorvastatin in renal impairment?

Answer 2

Renal impairment increases the risk of myopathy and rhabdomyolysis

Question 3

What is a serological marker that can be used to check for necrotising myopathy?

Answer 3

Anti-signal recognition particle (SRP) antibodies

Question 4

What is a serological marker that can be used to check for rhabdomyolysis?

Answer 4

Total creatine kinase elevation is a sensitive but nonspecific marker for rhabdomyolysis.

Question 5

How should atorvastatin be used in renal impairment?

Answer 5

Start at a low dose and monitor renal function and creatine kinase (CK) regularly.

Question 6

What is the active ingredient in Lescol?

Answer 6

Fluvastatin