Week 5 - Acid-Controlling Drugs Flashcards
what 3 types of receptors trigger stomach acid production
- gastrin
- ACh
- histamine
what is the function of the proton pump
- pumps H+ from the parietal cell into the stomach lumen
- the H+ then combined with Cl to create stomach acid
describe the carbonic anahydrase rxn
- CO2 is combined with H2O to create carbonic acid
- carbonic acid is broken down into H+ and HCO3- (bicarb) by carbonic anahydrase
- the H+ gets transported into the cell via the proton pump
- the bicarb gets shifted out of the cell
what is the alkaline tide
- an efflux of bicarb into the blood after acid secretion in the stomach
list the 3 types of acid-controlling drug
- antacids
- H2 antagonists
- proton pump inhibitors
what is the primary function of antacids
- neutralize stomach acids
what is the secondary function of antacids
- promote gastric mucosal defense mechanisms
list 3 ways that antacids promote gastric mucosal defense mechanisms
thru the secretion of:
- mucus
- bicarb
- prostaglandins
how does mucus provide protection
- protective barrier against HCl
how does bicarb provide protection
- helps buffer acidic properties of HCl
how do prostaglandins provide protection
- prevent activation of the proton pump & stimulates mucus production
describe the onset of antacids
- typically very quick
list 4 different types of antacids
- aluminum salts
- magnesium salts
- calcium salts
- sodium bicarb
how are antacids used?
- used alone or in combo with each other
what is the main side effect of aluminum salts
- constipation
how is the side effect of aluminum salts avoided? how does this work?
- often used with magnesium to counteract constipation
- a side effect of magnesium is diarrhea = cancel each other out
what type of patients are aluminum salts often recommended for? why?
- pts with renal disease
- bc they are more easily excreted
what is an example of an aluminum salt
- aluminum hydroxide salt = amphojel
what is a common side effect of magnesium salts? how is this avoided?
- diarrhea
- often combined w other drugs to counteract this effect
what kind of patients should magnesium salts not be used in? why?
- in pts with renal failure
- bc the failing kidney cannot excrete extra magnesium = accumulation
list 2 examples of magnesium salts
- magnesium hydroxide (milk of magnesia)
- magnesium carbonate = gaviscon ( can also be a combo)