Week 5 - Acid-Controlling Drugs Flashcards

1
Q

what 3 types of receptors trigger stomach acid production

A
  • gastrin
  • ACh
  • histamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is the function of the proton pump

A
  • pumps H+ from the parietal cell into the stomach lumen

- the H+ then combined with Cl to create stomach acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

describe the carbonic anahydrase rxn

A
  • CO2 is combined with H2O to create carbonic acid
  • carbonic acid is broken down into H+ and HCO3- (bicarb) by carbonic anahydrase
  • the H+ gets transported into the cell via the proton pump
  • the bicarb gets shifted out of the cell
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the alkaline tide

A
  • an efflux of bicarb into the blood after acid secretion in the stomach
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

list the 3 types of acid-controlling drug

A
  • antacids
  • H2 antagonists
  • proton pump inhibitors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the primary function of antacids

A
  • neutralize stomach acids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the secondary function of antacids

A
  • promote gastric mucosal defense mechanisms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

list 3 ways that antacids promote gastric mucosal defense mechanisms

A

thru the secretion of:

  • mucus
  • bicarb
  • prostaglandins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

how does mucus provide protection

A
  • protective barrier against HCl
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how does bicarb provide protection

A
  • helps buffer acidic properties of HCl
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

how do prostaglandins provide protection

A
  • prevent activation of the proton pump & stimulates mucus production
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

describe the onset of antacids

A
  • typically very quick
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

list 4 different types of antacids

A
  • aluminum salts
  • magnesium salts
  • calcium salts
  • sodium bicarb
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how are antacids used?

A
  • used alone or in combo with each other
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the main side effect of aluminum salts

A
  • constipation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how is the side effect of aluminum salts avoided? how does this work?

A
  • often used with magnesium to counteract constipation

- a side effect of magnesium is diarrhea = cancel each other out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what type of patients are aluminum salts often recommended for? why?

A
  • pts with renal disease

- bc they are more easily excreted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what is an example of an aluminum salt

A
  • aluminum hydroxide salt = amphojel
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what is a common side effect of magnesium salts? how is this avoided?

A
  • diarrhea

- often combined w other drugs to counteract this effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what kind of patients should magnesium salts not be used in? why?

A
  • in pts with renal failure

- bc the failing kidney cannot excrete extra magnesium = accumulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

list 2 examples of magnesium salts

A
  • magnesium hydroxide (milk of magnesia)

- magnesium carbonate = gaviscon ( can also be a combo)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what are 2 examples of magnesium combo products

A
  • Maalox & Mylanta (aluminum & magnesium)
23
Q

what is the most common form of calcium salts

A
  • calcium carbonate
24
Q

what are 2 side effects of calcium salts

A
  • constipation

- kidney stones

25
Q

how can calcium salts cause kidney stones

A
  • bc too much calcium can lead to the development
26
Q

what kind of patients should calcium salts not be used in? why?

A
  • not recommended for pts with renal disease

- bc may accumulate to toxic lvls

27
Q

describe the duration of calcium salts; what does this cause? how?

A
  • long duration of acid action
  • this can cause hyperacidity rebound
  • bc the acid secretion is being blocked for so long, the stomach produces a ton of gastrin to try and compensate. so once the individual stops taking the med, all of that gastrin can suddenly trigger acid production
28
Q

what are calcium salts often advertised as

A
  • an extra source of dietary calcium
29
Q

what is an example of calcium salts

A
  • tums = calcium carbonate
30
Q

what is the MOA of histamine type 2 antagonsist (2)

A
  • reduce acid secretion by blocking the action of histamine at the H2 receptors of acid-producing parietal cells
  • reduce the production of H+ ions = reduced HCl
31
Q

how are H2 antagonists available?

A
  • all available OTC in lower dosage forms
32
Q

how effective are H2 antagonists

A
  • provide a 25-75% decrease in acid production
33
Q

list 1 example of H2 antagonists

A
  • ranitidine (Zantac)
34
Q

what is the most popular drug for treatment of acid-related disorders

A

H2 antagonists

35
Q

what is a drug interaction associated eith H2 antagonists

A
  • smoking decreases the effectiveness of H2 blockers
36
Q

what is the MOA of proton pump inhibitors

A
  • irreversibly bind to H+/K+ ATPase enzyme (which are responsible for the proton pump)
  • this bond prevents the movement of H+ ions from the parietal cell into the stomach
37
Q

how effective are proton pump inhibitors

A

block 100% of acid production for 24h

38
Q

what do proton pump inhibitors result in? what is this?

A
  • achlorhydria

- ALL gastric acid secretion is temporily blocked

39
Q

what must happen for the cell to return to normal acid secretion after treatment w a proton pump inhibitor

A
  • the parietal cell must synthesize new H+/K+ ATPase

- which takes ~1 day

40
Q

what is an example of a proton pump inhibitor

A
  • omeprazole (prilosec or Losec)
41
Q

describe the short term adverse effect of proton pump inhibitors

A
  • HA
  • diarrhea
  • NV
42
Q

describe the long term side effects of proton pump inhibitors (3)

A
  • pneumonia
  • fractures (low) due to low calcium absorption
  • rebound hypersecretion
43
Q

what is a fear associated with proton pump inhibitors

A
  • fear of increased risk of infection (lack of acid could cause bacteria overgrowth)
44
Q

list 2 miscellaneous peptic ulcer drugs

A
  • sucralfate (carafate)

- misoprostol (cytotec)

45
Q

what is sucralfate

A
  • coating agent & cytoprotective drug
46
Q

what is sucralfate used for

A
  • stress ulcers

- peptic ulcer disease

47
Q

what is the MOA of sucralfate

A
  • attracted to & binds to the base of ulcers & erosions, forming a protective barrier over these areas
  • protects these areas from pepsin = prevents the ulcers from worsening
48
Q

what is misoprostol

A
  • synthetic prostaglandin analog

= can artifically restore prostaglandin cytoprotective activity

49
Q

describe the cytoprotective activity of prostaglandin (4)

A
  • protect gastric mucosa from injury by enhancing local production of mucus
  • inhibits acid production at higher doses
  • promotes local cell regeneration
  • helps maintain mucosal blood flow
50
Q

what is misoprostol specifically used for

A
  • prevention of NSAID induced gastric ulcers
51
Q

describe side effects of misoprostol

A

doses that are therapeutic enough to treat duodenal ulcers often produce:

  • abdominal cramps
  • diarrhea
52
Q

describe the side effects of H2 receptor antagonists

A
  • very few

- may increase risk of aspiration

53
Q

what is one thing to consider with antacids

A
  • give one hour apart from H2 antagonists and sulcrafate
54
Q

describe the general safety of proton pump inhibitors

A
  • generally v safe & tolerated well with few side effects