Week 10 - Huntington's Disease Flashcards
1
Q
what is huntington’s disease
A
- neurodegenerative genetic disorder that involves degeneration of neurons in the basal ganglia
2
Q
what nt are involved in huntington’s disease (2)
A
- ach
- dopamine
3
Q
describe the balance of ach and dopamine in huntington’s disease
A
- excess dopamine
- deficiency in ach
4
Q
list symptoms of huntington’s disease (2)
A
- excessive and abnormal involuntary movements
- psychiatric abnormalities (Mental decline)
5
Q
what are the abnormal involuntary movements in huntington’s disease called
A
- cholera
6
Q
what pyschiatric abnormalities are seen during huntington’s disease (6)
A
- depression
- anxiety
- irritability
- anger
- forgetfulness
- impaired judgement
7
Q
what effect do the symptoms of huntington’s disease have on motor function (5)
A
- unsteady gait
- writhing
- twisting movement of body & face
- speech & swallowing issues
8
Q
what can the mental decline in huntington’s lead to
A
- dementia
9
Q
describe diagnosis of huntingtons
A
- combo of family history & clinical symptoms review
- genetic testing in symptomatic individuals
10
Q
what is ALS
A
- amyotrophic lateral sclerosis
11
Q
what are symptoms of ALS
A
- muscle weakness & atrophy throughout the body
12
Q
what does ALS cause
A
- degeneration of the upper & lower motor neurons
13
Q
what is the cause of ALS (2)
A
- 10% genetic
- 90& idiopathic
